[白细胞介素-6基因-572C>G多态性与江苏和安徽地区中国汉族人群前列腺癌易感性的关联]

[Association of IL-6-572C > G polymorphism with the susceptibility to prostate cancer in the Chinese Han population in Jiangsu and Anhui area].

作者信息

Lu Xiao-Ming, Hua Li-Xin, Wang Jin-Feng

机构信息

Department of Urology, Yancheng Hospital Affiliated to Southeast University, Yancheng, Jiangsu 224001, China.

出版信息

Zhonghua Nan Ke Xue. 2011 Aug;17(8):707-11.

PMID:21898993

Abstract

OBJECTIVE

To investigate the association of the IL-6 -572C > G polymorphism with the risk of prostate cancer (PCa) in the Chinese Han population in Jiangsu and Anhui area.

METHODS

We obtained peripheral blood genome DNA from 200 PCa patients and 279 age-matched PCa-free healthy controls, analyzed the site polymorphism of IL-6 -572C > G with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, and studied the correlation of different genotypes with the susceptibility to PCa.

RESULTS

The subjects that carried the CCGG genotype had a risk of PCa 2.46 times that of the CC genotype carriers (95% CI = 1.41-4.29), and 2.47 times that of the CC/GC genotype carriers (95% CI = 1.47-4.17). This risk was significantly increased among the following subgroups of CCGG genotype carriers: age > 70 yr (OR = 3.06, 95% CI: 1.44-6.49), BMI > 23 kg/m2 (OR = 3.72, 95% CI: 1.79-7.74), no cigarette smoking (OR = 2.96, 95% CI: 1.30-6.72), alcohol drinking (OR = 2.73, 95% CI: 1.28-5.79), with a family history of cancer (OR = 6.67, 95% CI: 1.50-29.69).

CONCLUSION

In the Chinese Han population in Jiangsu and Anhui area, IL-6 -572C > G polymorphism is associated with the susceptibility to PCa, and GG might be a susceptible genotype to PCa.

摘要

目的

探讨白细胞介素-6（IL-6）-572C＞G基因多态性与江苏和安徽地区中国汉族人群前列腺癌（PCa）风险的相关性。

方法

我们从200例PCa患者和279例年龄匹配的无PCa健康对照者中获取外周血基因组DNA，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术分析IL-6 -572C＞G位点多态性，并研究不同基因型与PCa易感性的相关性。

结果

携带CCGG基因型的受试者患PCa的风险是CC基因型携带者的2.46倍（95%可信区间[CI]=1.41-4.29），是CC/GC基因型携带者的2.47倍（95%CI=1.47-4.17）。在CCGG基因型携带者的以下亚组中，这种风险显著增加：年龄＞70岁（比值比[OR]=3.06，95%CI：1.44-6.49）、体重指数（BMI）＞23kg/m²（OR=3.72，95%CI：1.79-7.74）、不吸烟（OR=2.96，95%CI：1.30-6.72）、饮酒（OR=2.73，95%CI：1.28-5.79）、有癌症家族史（OR=6.67，95%CI：1.50-29.69）。