Department of Vascular Surgery, Imperial College London, London, UK.
Angiology. 2011 May;62(4):317-28. doi: 10.1177/0003319710384397.
We estimated the value of objective, computerized texture analysis of ultrasonic images in distinguishing carotid plaques associated with neurological ipsilateral symptoms (amaurosis fugax [AmF; n = 30], transient ischemic attack [TIA; n = 52], and stroke [n = 55]) from asymptomatic plaques (n = 51). We performed 3 case-control studies (1/symptom with asymptomatic plaques as control). On logistic regression, AmF was independently associated with severity of stenosis, percentage of pixels with gray levels 0 to 10 (PPCS1; measure of echolucency), and spatial gray level dependence matrices (SGLDM) information measure of correlation (IMC-1; texture); TIAs with PPCS1 (echolucency), SGLDM correlation, and skewness (both texture); and stroke with PPCS1, SGLDM correlation, and percentage of pixels with gray levels 11 to 20 (PPCS2; echolucency). The area under the curve of the regression-derived predicted probability for AmF, TIA, and stroke was 0.92, 0.82, and 0.85, respectively (all P < .001). Texture analysis can identify carotid plaques associated with a neurological event, improving the diagnostic value of echolucency measures. Texture analyses could be applied to natural history studies.
我们评估了超声图像客观、计算机化纹理分析在区分与同侧神经症状（一过性黑矇[AmF；n = 30]、短暂性脑缺血发作[TIA；n = 52]和中风[n = 55]）相关的颈动脉斑块与无症状斑块（n = 51）方面的价值。我们进行了 3 项病例对照研究（以每 1 个症状患者配对 1 个无症状斑块患者作为对照）。在逻辑回归分析中，AmF 与狭窄严重程度、灰度水平为 0 到 10 的像素百分比（PPCS1；衡量回声衰减程度）以及空间灰度依赖性矩阵（SGLDM）信息相关度量（IMC-1；纹理）独立相关；TIA 与 PPCS1（回声衰减程度）、SGLDM 相关和偏度（均为纹理）相关；而中风与 PPCS1、SGLDM 相关和灰度水平为 11 到 20 的像素百分比（PPCS2；回声衰减程度）相关。基于回归推导的预测概率的曲线下面积，AmF、TIA 和中风的分别为 0.92、0.82 和 0.85（均<0.001）。纹理分析可以识别与神经事件相关的颈动脉斑块，提高回声衰减程度测量的诊断价值。纹理分析可应用于自然史研究。
