Hammad F T, Lubbad L
Department of Surgery, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Eur Surg Res. 2011;46(4):188-93. doi: 10.1159/000324414. Epub 2011 Apr 6.
To investigate the effect of curcumin on the alterations in renal functional parameters following reversible unilateral ureteric obstruction in the rat.
Wistar rats underwent reversible left ureteric obstruction for 72 h. The group Cm (n = 7) received oral curcumin (200 mg/kg/day), whereas the Vx group (n = 8) had only a vehicle.
Ureteric obstruction caused a significant increase in the serum tumour necrosis factor α in both groups. However, the post-obstruction level in the Cm group was significantly lower than in the Vx group. In the Vx group, the glomerular filtration rate, renal blood flow, urine volume and urinary sodium excretion in the left obstructed kidney were significantly lower than those in the right kidney, but the fractional excretion of sodium was comparable in the 2 groups. The left kidney in the Cm group behaved similar to that in the Vx group. Moreover, there was no difference in any variable when comparing the right and left kidneys among the groups.
Curcumin appears to have no significant protective effect on the haemodynamic or tubular glomerular functions when measured as early as 3 days following reversible ureteric obstruction despite the amelioration in some of the indicators of renal injury.
研究姜黄素对大鼠可逆性单侧输尿管梗阻后肾功能参数变化的影响。
Wistar大鼠接受可逆性左输尿管梗阻72小时。Cm组（n = 7）口服姜黄素（200毫克/千克/天），而Vx组（n = 8）仅给予赋形剂。
输尿管梗阻导致两组血清肿瘤坏死因子α显著升高。然而，Cm组梗阻后的水平显著低于Vx组。在Vx组中，左梗阻肾脏的肾小球滤过率、肾血流量、尿量和尿钠排泄显著低于右肾，但两组的钠排泄分数相当。Cm组的左肾表现与Vx组相似。此外，比较各组左右肾时，任何变量均无差异。
尽管肾损伤的一些指标有所改善，但在可逆性输尿管梗阻后3天早期测量时，姜黄素似乎对血流动力学或肾小管肾小球功能没有显著的保护作用。
