Laboratory of Laser Molecular Spectroscopy, Institute of Applied Radiation Chemistry, Technical University of Lodz, Wroblewskiego 15, 93-590 Lodz, Poland.
J Med Chem. 2011 May 12;54(9):3386-92. doi: 10.1021/jm200180f. Epub 2011 Apr 15.
We present the results of differential scanning calorimetry (DSC) and Raman studies in the temperature range of 293-77 K on vibrational properties of the oleic acid and the human breast tissue as a function of temperature. We have found that vibrational properties are very sensitive indicators to specify phases and phase transitions at the molecular level. We have found that water content confined in the cancerous tissue is markedly different from that in the noncancerous tissue. The OH stretching vibrations of water are useful as potential Raman biomarkers to distinguish between the cancerous and the noncancerous human breast tissues. Our results provide experimental evidence on the role of lipid profile and cell hydration as factors of particular significance in differentiation of the noncancerous and cancerous breast tissues.
我们展示了差示扫描量热法（DSC）和拉曼研究的结果，研究了油酸和人体乳腺组织在 293-77 K 温度范围内的振动特性随温度的变化。我们发现，振动特性是在分子水平上指定相和相变的非常敏感的指标。我们发现，局限在癌组织中的水分含量与非癌组织中的水分含量明显不同。水的 OH 伸缩振动是区分癌组织和非癌组织的潜在拉曼生物标志物。我们的研究结果提供了实验证据，表明脂质分布和细胞水合作用作为区分非癌组织和癌组织的重要因素。
