在韩国，对肠胃炎患儿进行人类肠道孤儿病毒检测。
Detection of human parechoviruses in children with gastroenteritis in South Korea.
机构信息
Department of Laboratory Medicine, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Korea.
出版信息
Arch Virol. 2011 Aug;156(8):1471-5. doi: 10.1007/s00705-011-0995-y. Epub 2011 Apr 11.
Human parechoviruses (HPeVs) are associated with gastroenteritis (GE), although their etiologic role is uncertain. The purpose of this study was to detect HPeVs in children with GE in Korea. A total of 348 stool samples that were negative for common enteric viruses were screened for HPeV using RT-PCR. Of the 348 stool samples, seven (2.0%) were positive for HPeV. Five Korean strains belonged to HPeV-1, and two strains belonged to HPeV-4. Four Korean HPeV-1 strains clustered with strain 7555312 and the other HPeV-1 strain clustered with the BNI-788St strain. Two HPeV-4 strains showed discordant phylogenic relationships in the 3D gene, suggesting that recombination had occurred. This is the first study reporting the detection of HPeVs in children with GE in Korea.
人类肠道病毒（HPeVs）与胃肠炎（GE）有关，但其病因作用尚不确定。本研究旨在检测韩国儿童GE 中 HPeVs 的情况。使用 RT-PCR 对 348 份经普通肠道病毒检测为阴性的粪便样本进行 HPeV 筛查。在 348 份粪便样本中，有 7 份（2.0%） HPeV 呈阳性。5 株韩国株属于 HPeV-1，2 株属于 HPeV-4。4 株韩国 HPeV-1 株与菌株 7555312 聚类，另一株 HPeV-1 株与 BNI-788St 株聚类。2 株 HPeV-4 株在 3D 基因上表现出不同的系统发育关系，提示发生了重组。这是首例在韩国儿童 GE 中检测到 HPeVs 的报告。
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