脐带：丰富而符合伦理的干细胞来源，推动再生医学发展。
The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine.
机构信息
CTI-LYON, Cell Therapy Research Institute, Parc Technologique de Lyon St Priest, France.
出版信息
Cell Prolif. 2011 Apr;44 Suppl 1(Suppl 1):60-9. doi: 10.1111/j.1365-2184.2010.00729.x.
Abstract
Science and medicine place a lot of hope in the development of stem cell research and regenerative medicine. This review will define the concept of regenerative medicine and focus on an abundant stem cell source - neonatal tissues such as the umbilical cord. Umbilical cord blood has been used clinically for over 20 years as a cell source for haematopoietic stem cell transplantation. Beyond this, cord blood and umbilical cord-derived stem cells have demonstrated potential for pluripotent lineage differentiation (liver, pancreatic, neural tissues and more) in vitro and in vivo. This promising research has opened up a new era for utilization of neonatal stem cells, now used beyond haematology in clinical trials for autoimmune disorders, cerebral palsy or type I diabetes.
摘要
科学和医学对干细胞研究和再生医学的发展寄予厚望。这篇综述将定义再生医学的概念，并重点介绍一种丰富的干细胞来源——新生儿组织，如脐带。脐带血作为造血干细胞移植的细胞来源，已经在临床上使用了 20 多年。除此之外，脐带血和脐带衍生的干细胞已经证明具有多能系分化的潜力（肝脏、胰腺、神经组织等），无论是在体外还是体内。这项有前景的研究为新生儿干细胞的利用开辟了一个新时代，现在除了血液学之外，在临床试验中还用于自身免疫性疾病、脑瘫或 I 型糖尿病的治疗。
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