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伊卡宁 Senegalensis（铁青树科），传统上用于治疗疟疾，抑制体外疟原虫生长而不宿主细胞毒性。

Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity.

机构信息

Equipe de Chimie Analytique des Molécules BioActives IPHC-LC4, UMR 7178, Faculté de Pharmacie, 74, route du Rhin, 67400, Illkirch, France.

出版信息

Malar J. 2011 Apr 11;10:85. doi: 10.1186/1475-2875-10-85.

DOI:10.1186/1475-2875-10-85
PMID:21481272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3090372/
Abstract

BACKGROUND

With the aim of discovering new natural active extracts against malaria parasites, Icacina senegalensis was selected after an ethnopharmacological survey conducted on plants used in traditional malaria treatment in Senegal.

METHODS

Different concentrations of the plant extract and fractions were tested on synchronized Plasmodium falciparum cultures at the ring stage using the parasite lactate dehydrogenase assay. Their haemolytic activity and in vitro cytoxicity were evaluated. The chromatographic profiles of active fractions were also established.

RESULTS

The plant extract and fractions revealed anti-plasmodial activity (IC50 < 5 μg/mL) with no toxicity (Selectivity indexes >10). The dichloromethane fraction showed stronger anti-plasmodial activity than the total extract.

CONCLUSION

Anti-plasmodial activity and toxicity of I. senegalensis are reported for the first time and showed promising results in malaria field research.

摘要

背景

为了发现新的天然抗疟寄生虫活性提取物，在对塞内加尔传统疟疾治疗中使用的植物进行了民族药理学调查后，选择了伊卡宁塞内加尔ensis。

方法

采用寄生虫乳酸脱氢酶测定法，在环期阶段，用不同浓度的植物提取物和馏分对同步培养的恶性疟原虫进行了测试。评估了它们的溶血活性和体外细胞毒性。还建立了活性馏分的色谱图。

结果

该植物提取物和馏分具有抗疟活性（IC50<5μg/ml），无毒性（选择性指数>10）。二氯甲烷馏分显示出比总提取物更强的抗疟活性。

结论

首次报道了伊卡宁塞内加尔ensis 的抗疟活性和毒性，并在疟疾领域的研究中显示出有希望的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/3f9f1d185777/1475-2875-10-85-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/e1a12e614311/1475-2875-10-85-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/2798b259309d/1475-2875-10-85-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/3f9f1d185777/1475-2875-10-85-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/e1a12e614311/1475-2875-10-85-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/2798b259309d/1475-2875-10-85-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92e/3090372/3f9f1d185777/1475-2875-10-85-3.jpg

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