Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Fertil Steril. 2011 Jun 30;95(8):2464-6. doi: 10.1016/j.fertnstert.2011.03.026. Epub 2011 Apr 9.
Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.
虽然巨噬细胞集落刺激因子（CSF-1）被认为在维持子宫内膜异位症的慢性炎症反应中发挥作用，但我们的数据表明，CSF-1 也可能在早期子宫内膜异位症病变形成中发挥作用。我们已经表明，CSF-1 以自分泌的方式对子宫内膜上皮细胞的增殖和附着到腹膜间皮细胞具有直接影响，这是子宫内膜异位症病变在腹膜上形成的早期步骤。
