Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Trends Immunol. 2011 Jun;32(6):265-71. doi: 10.1016/j.it.2011.03.005. Epub 2011 Apr 12.
γδ T cells lie at the interface between innate and adaptive immunity, sharing features with both arms of the immune system. The vast majority of γδ T cells reside in epithelial layers of tissues such as skin, gut, lung, tongue and reproductive tract where they provide a first line of defense against environmental attack. The existence of epithelium-resident γδ T cells has been known for over 20 years but our understanding of the molecular events regulating development and function of these cells is incomplete. We review recent advances in the field, with particular emphasis on the γδ T cell population resident in mouse epidermis. These studies have enhanced our knowledge and understanding of the life cycle of this enigmatic population of cells.
γδ T 细胞位于先天免疫和适应性免疫的交界处，兼具免疫系统两个分支的特征。绝大多数 γδ T 细胞存在于皮肤、肠道、肺、舌和生殖道等组织的上皮层中，在那里它们为抵御环境攻击提供了第一道防线。上皮组织驻留 γδ T 细胞的存在已经有 20 多年了，但我们对调节这些细胞发育和功能的分子事件的理解并不完整。我们综述了该领域的最新进展，特别强调了驻留在小鼠表皮中的 γδ T 细胞群体。这些研究提高了我们对这个神秘细胞群体的生命周期的认识和理解。
