• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

三位一体：炎症、细胞因子和 STAT3 塑造癌症微环境。

The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment.

机构信息

Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

出版信息

Cancer Cell. 2011 Apr 12;19(4):429-31. doi: 10.1016/j.ccr.2011.03.018.

DOI:10.1016/j.ccr.2011.03.018
PMID:21481782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3111086/
Abstract

Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited inflammation in the development and progression of pancreatic ductal adenocarcinoma and esophageal squamous carcinoma. Disruption of tissue homeostasis culminates in activation of STAT3, generating a pro-tumorigenic inflammatory microenvironment.

摘要

肿瘤相关炎症是肿瘤发生的结果和驱动因素。本期《癌细胞》中的三篇论文表明了肿瘤引发的炎症在胰腺导管腺癌和食管鳞癌的发生和发展中的重要性。组织平衡的破坏最终导致 STAT3 的激活，产生有利于肿瘤发生的炎症微环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff8/3111086/8c0fd28fec9b/nihms287834f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff8/3111086/8c0fd28fec9b/nihms287834f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff8/3111086/8c0fd28fec9b/nihms287834f1.jpg

相似文献

1
The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment.三位一体：炎症、细胞因子和 STAT3 塑造癌症微环境。
Cancer Cell. 2011 Apr 12;19(4):429-31. doi: 10.1016/j.ccr.2011.03.018.
2
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.胰腺癌细胞的鳞状转化促进了基质炎症。
Elife. 2020 Apr 24;9:e53381. doi: 10.7554/eLife.53381.
3
Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model.脂多糖 (LPS) 刺激胰腺导管腺癌 (PDAC) 和巨噬细胞激活 NLRP3 炎性体，影响共培养模型中促炎细胞因子的水平。
Cancer Biol Ther. 2023 Dec 31;24(1):2284857. doi: 10.1080/15384047.2023.2284857. Epub 2023 Nov 29.
4
BP1003 Decreases STAT3 Expression and Its Pro-Tumorigenic Functions in Solid Tumors and the Tumor Microenvironment.BP1003降低实体瘤及肿瘤微环境中信号转导和转录激活因子3（STAT3）的表达及其促肿瘤发生功能。
Biomedicines. 2024 Aug 20;12(8):1901. doi: 10.3390/biomedicines12081901.
5
Inflammatory microenvironment of fibrotic liver promotes hepatocellular carcinoma growth, metastasis and sorafenib resistance through STAT3 activation.纤维化肝脏的炎症微环境通过 STAT3 激活促进肝癌生长、转移和索拉非尼耐药。
J Cell Mol Med. 2021 Feb;25(3):1568-1582. doi: 10.1111/jcmm.16256. Epub 2021 Jan 7.
6
Emerging roles for the IL-6 family of cytokines in pancreatic cancer.白细胞介素 6 家族细胞因子在胰腺癌中的新作用。
Clin Sci (Lond). 2020 Aug 28;134(16):2091-2115. doi: 10.1042/CS20191211.
7
Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide.使用 STAT3 反义寡核苷酸抑制髓源性抑制细胞可增强胰腺导管腺癌对放疗的反应。
Cancer Immunol Immunother. 2021 Apr;70(4):989-1000. doi: 10.1007/s00262-020-02701-w. Epub 2020 Oct 23.
8
GATA4 Regulates Inflammation-Driven Pancreatic Ductal Adenocarcinoma Progression.GATA4调控炎症驱动的胰腺导管腺癌进展。
Front Cell Dev Biol. 2021 Apr 29;9:640391. doi: 10.3389/fcell.2021.640391. eCollection 2021.
9
Tumor microenvironment and Oral Squamous Cell Carcinoma: A crosstalk between the inflammatory state and tumor cell migration.肿瘤微环境与口腔鳞状细胞癌：炎症状态与肿瘤细胞迁移的相互作用。
Oral Oncol. 2021 Jan;112:105038. doi: 10.1016/j.oraloncology.2020.105038. Epub 2020 Oct 28.
10
Role of STAT3 in pancreatic cancer.信号转导与转录激活因子3（STAT3）在胰腺癌中的作用。
Explor Target Antitumor Ther. 2024;5(5):20-34. doi: 10.37349/etat.2024.00202. Epub 2024 Jan 17.

引用本文的文献

1
Exercise-Mediated Skeletal Muscle-Derived IL-6 Regulates Bone Metabolism: A New Perspective on Muscle-Bone Crosstalk.运动介导的骨骼肌来源的白细胞介素-6调节骨代谢：肌肉-骨相互作用的新视角
Biomolecules. 2025 Jun 18;15(6):893. doi: 10.3390/biom15060893.
2
Dual role of autophagy in bone metastasis: mechanistic insights and therapeutic targeting.自噬在骨转移中的双重作用：机制洞察与治疗靶点
Am J Clin Exp Urol. 2025 Apr 25;13(2):92-117. doi: 10.62347/QCPV6064. eCollection 2025.
3
Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma.

本文引用的文献

1
Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.p120 连环蛋白缺失导致具有炎症和癌症的肿瘤微环境，将其确立为肿瘤抑制基因。
Cancer Cell. 2011 Apr 12;19(4):470-83. doi: 10.1016/j.ccr.2011.02.007.
2
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.白细胞介素 6 转染信号通过 Stat3/Socs3 的激活促进胰腺上皮内瘤变的进展和胰腺癌的发生。
Cancer Cell. 2011 Apr 12;19(4):456-69. doi: 10.1016/j.ccr.2011.03.009.
3
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
透明细胞肾细胞癌的肿瘤起始细胞和转移起始细胞
J Biomed Sci. 2025 Feb 8;32(1):17. doi: 10.1186/s12929-024-01111-9.
4
Intratumor microbiota and colorectal cancer: Comprehensive and lucid review.肿瘤内微生物群与结直肠癌：全面而清晰的综述。
Chin J Cancer Res. 2024 Dec 30;36(6):683-699. doi: 10.21147/j.issn.1000-9604.2024.06.07.
5
Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19 - A Case Discussion That Raises Many Unknown Questions About Covid-19.新型冠状病毒肺炎后免疫反应所致间变性室管膜瘤和非典型难治性纵向扩展性横贯性脊髓炎——引发诸多关于新型冠状病毒肺炎未知问题的病例讨论
Noro Psikiyatr Ars. 2023 Nov 21;61(4):370-373. doi: 10.29399/npa.28464. eCollection 2024.
6
Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer.双重 JAK/HDAC 抑制剂联合regorafenib 协同减少结直肠癌的肿瘤生长、转移和regorafenib 诱导的毒性。
J Exp Clin Cancer Res. 2024 Jul 11;43(1):192. doi: 10.1186/s13046-024-03106-8.
7
To explore the mechanism of Yigong San anti-gastric cancer and immune regulation.探讨益宫散抗胃癌及免疫调节的机制。
World J Gastrointest Oncol. 2024 May 15;16(5):1965-1994. doi: 10.4251/wjgo.v16.i5.1965.
8
Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment.肿瘤细胞相关的白细胞介素-1α通过操纵肿瘤免疫微环境影响小鼠乳腺癌的进展和转移。
Int J Mol Sci. 2024 Apr 2;25(7):3950. doi: 10.3390/ijms25073950.
9
Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment.用于胰腺癌治疗的高选择性强效信号转导和转录激活因子3（STAT3）抑制剂的发现。
ACS Cent Sci. 2024 Feb 10;10(3):579-594. doi: 10.1021/acscentsci.3c01440. eCollection 2024 Mar 27.
10
RUNX1-Regulated Signaling Pathways in Ovarian Cancer.RUNX1调控的卵巢癌信号通路
Biomedicines. 2023 Aug 23;11(9):2357. doi: 10.3390/biomedicines11092357.
Stat3 和 MMP7 有助于胰腺导管腺癌的发生和进展。
Cancer Cell. 2011 Apr 12;19(4):441-55. doi: 10.1016/j.ccr.2011.03.002.
4
Hallmarks of cancer: the next generation.癌症的特征：下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
5
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.肿瘤浸润调节性 T 细胞通过 RANKL-RANK 信号促进乳腺癌转移。
Nature. 2011 Feb 24;470(7335):548-53. doi: 10.1038/nature09707. Epub 2011 Feb 16.
6
Immunity, inflammation, and cancer.免疫、炎症与癌症。
Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.
7
STATs in cancer inflammation and immunity: a leading role for STAT3.信号转导和转录激活因子在癌症炎症与免疫中的作用：信号转导和转录激活因子3起主导作用
Nat Rev Cancer. 2009 Nov;9(11):798-809. doi: 10.1038/nrc2734.
8
Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway.基质金属蛋白酶7通过激活Notch信号通路来控制胰腺腺泡细胞的转分化。
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19327-32. doi: 10.1073/pnas.0705953104. Epub 2007 Nov 27.
9
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.慢性胰腺炎对于成年小鼠中K-Ras癌基因诱导胰腺导管腺癌至关重要。
Cancer Cell. 2007 Mar;11(3):291-302. doi: 10.1016/j.ccr.2007.01.012.
10
A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers.身份错认的案例？胰腺“导管”癌的非导管起源
Cancer Cell. 2007 Mar;11(3):211-3. doi: 10.1016/j.ccr.2007.02.020.