三位一体：炎症、细胞因子和 STAT3 塑造癌症微环境。
The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment.
机构信息
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Cancer Cell. 2011 Apr 12;19(4):429-31. doi: 10.1016/j.ccr.2011.03.018.
Abstract
Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited inflammation in the development and progression of pancreatic ductal adenocarcinoma and esophageal squamous carcinoma. Disruption of tissue homeostasis culminates in activation of STAT3, generating a pro-tumorigenic inflammatory microenvironment.
摘要
肿瘤相关炎症是肿瘤发生的结果和驱动因素。本期《癌细胞》中的三篇论文表明了肿瘤引发的炎症在胰腺导管腺癌和食管鳞癌的发生和发展中的重要性。组织平衡的破坏最终导致 STAT3 的激活，产生有利于肿瘤发生的炎症微环境。
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