Gemici Yağmur İnalkaç, Çelik Fatih, Göz Zeynep Zerrin, İşisağ Aydın, Ovalı Gülgün Yılmaz, Zileli Mehmet, Barutçuoğlu Mustafa, Mavioğlu Hatice
Manisa Celal Bayar University Faculty of Medicine, Departmant of Neurology, Manisa, Türkiye.
Manisa Celal Bayar University Faculty of Medicine, Departmant of Pathology, Manisa, Türkiye.
Noro Psikiyatr Ars. 2023 Nov 21;61(4):370-373. doi: 10.29399/npa.28464. eCollection 2024.
Inflammatory neurologic manifestations, both infectious and non-infectious, have been reported secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19). However, the relationship of spinal tumor and COVID-19 longitudinally extensive transverse myelitis (LETM) coexistence has never been reported in our knowledge. The clinical presentation and response to treatment of a 24-year-old female patient diagnosed with COVID-19 LETM and anaplastic ependymoma are described in this case report. The Patient's cerebrospinal fluid COVID-19 antibody level was higher than serum and she was resistant to immunosuppressive treatment. The interaction between COVID-19 and spinal tumor was discussed in the light of the literature. It is thought that COVID-19 infection could trigger tumor growth in this patient. Also, this is the first case of anaplastic ependymoma and COVID-19 myelitis coexistence in the literature.
已有报道称，严重急性呼吸综合征冠状病毒2（SARS-CoV-2/新冠病毒病）继发有感染性和非感染性炎性神经表现。然而，据我们所知，脊髓肿瘤与新冠病毒病纵向广泛横贯性脊髓炎（LETM）并存的关系从未有过报道。本病例报告描述了一名24岁女性患者的临床表现及治疗反应，该患者被诊断为新冠病毒病LETM并患有间变性室管膜瘤。患者脑脊液中的新冠病毒病抗体水平高于血清，且对免疫抑制治疗有抵抗性。结合文献对新冠病毒病与脊髓肿瘤之间的相互作用进行了讨论。据认为，新冠病毒感染可能引发了该患者肿瘤的生长。此外，这是文献中首例间变性室管膜瘤与新冠病毒脊髓炎并存的病例。
