Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, 200233, People's Republic of China.
Mol Biol Rep. 2012 Jan;39(1):269-75. doi: 10.1007/s11033-011-0735-0. Epub 2011 May 31.
MicroRNAs (miRNAs) are small non-coding RNA molecules that function as negative regulators of gene expression. Common genetic variants (single nucleotide polymorphisms, SNPs) in miRNA genes may alter their expression or maturation resulting in varied functional consequences. Until now, several studies had evaluated the association between the polymorphisms in the hsa-miR-196a2 rs11614913 and cancer risk in diverse populations and in multiple types of cancer, with contradictory outcomes. Therefore, here we performed a meta-analysis to address the association between this polymorphism and cancer risk. A total of nine studies involving 6,540 cases and 7,562 controls were retrieved based on PubMed. Our analysis demonstrated that hsa-miR-196a2 rs11614913 CC genotype significantly increased the cancer risk in homozygote comparison model compared to TT genotype (OR=1.18; 95% CI, 1.01-1.68). Moreover, significant association of this polymorphism with breast cancer was found based on homozygote comparison model (OR=1.30; 95% CI, 1.01-1.26) and dominant model (OR=1.11; 95% CI, 1.01-1.23). In addition, hsa-miR-196a2 rs11614913 CC genotype was significantly associated with cancer risk in Chinese and Indian (OR=1.21; 95% CI, 1.05-1.40), but not in Caucasians (OR=1.03; 95% CI, 0.89-1.19). Taken together, our results indicate that the polymorphism of hsa-miR-196a2 rs11614913 is associated with cancer susceptibility, especially with breast cancer and in Chinese and Indian populations.
微小 RNA（miRNAs）是作为基因表达负调控因子的小非编码 RNA 分子。miRNA 基因中的常见遗传变异（单核苷酸多态性，SNP）可能改变它们的表达或成熟，从而产生不同的功能后果。到目前为止，已有几项研究评估了 hsa-miR-196a2 rs11614913 中的多态性与不同人群和多种癌症的癌症风险之间的关联，但其结果存在矛盾。因此，我们在这里进行了一项荟萃分析，以解决该多态性与癌症风险之间的关联。根据 PubMed 检索到的 9 项研究，共纳入了 6540 例病例和 7562 例对照。我们的分析表明，与 TT 基因型相比，hsa-miR-196a2 rs11614913 CC 基因型在纯合子比较模型中显著增加了癌症风险（OR=1.18；95%CI，1.01-1.68）。此外，基于纯合子比较模型（OR=1.30；95%CI，1.01-1.26）和显性模型（OR=1.11；95%CI，1.01-1.23）发现，该多态性与乳腺癌显著相关。此外，hsa-miR-196a2 rs11614913 CC 基因型与中国和印度人群的癌症风险显著相关（OR=1.21；95%CI，1.05-1.40），但与高加索人群无显著相关性（OR=1.03；95%CI，0.89-1.19）。综上所述，我们的研究结果表明，hsa-miR-196a2 rs11614913 的多态性与癌症易感性相关，尤其是与乳腺癌和中国及印度人群相关。
