Department of Oral and Maxillofacial Surgery, Clinical Navigation and Robotics, Charité-Campus Virchow Clinic, Berlin, Germany.
Int J Oral Maxillofac Implants. 2011 Mar-Apr;26(2):385-92.
In this prospective study, bone formation in human extraction sockets augmented with Bio-Oss Collagen after a 12-week healing period was quantified and compared to bone formation in unaugmented extraction sockets.
Selected patients with four-walled extraction sockets were included in this prospective study. After extraction, the sockets were randomly augmented using Bio-Oss Collagen or left to heal unfilled without raising a mucoperiosteal flap. At the time of implant placement, histologic specimens were obtained from the socket and analyzed. Statistical analysis was performed using the Wilcoxon signed-rank test.
Twenty-five patients with a total of 39 sockets (20 augmented, 19 unaugmented) were included in the study and the histologic specimens analyzed. All specimens were free of inflammatory cells. The mean overall new bone formation in the augmented sites was 25% (range, 8%-41%) and in the unaugmented sockets it was 44% (range, 3%-79%). There was a significant difference in the rate of new bone formation between the grafted and ungrafted sockets and a significant difference in the bone formation rate in the apical compared to the coronal regions of all sockets, independent of the healing mode.
This descriptive study demonstrated that bone formation in Bio-Oss Collagen-grafted human extraction sockets was lower than bone formation in ungrafted sockets. Bone formation occurred in all specimens with varying degrees of maturation independent of the grafting material and was initiated from the apical region.
在这项前瞻性研究中，定量比较了在 12 周愈合期后用 Bio-Oss 胶原增强的人拔牙窝中的骨形成，并与未增强的拔牙窝中的骨形成进行比较。
本前瞻性研究纳入了具有四壁拔牙窝的选定患者。拔牙后，随机使用 Bio-Oss 胶原增强或不翻瓣不填充骨缺损来使拔牙窝自然愈合。在植入物放置时，从牙槽窝中获得组织学标本并进行分析。使用 Wilcoxon 符号秩检验进行统计分析。
本研究共纳入 25 例患者的 39 个牙槽窝（20 个增强，19 个未增强），并对组织学标本进行了分析。所有标本均无炎症细胞。增强部位的总体新骨形成平均值为 25%（范围为 8%-41%），未增强部位为 44%（范围为 3%-79%）。增强和未增强牙槽窝之间的新骨形成率存在显著差异，所有牙槽窝的根尖区与冠区之间的骨形成率也存在显著差异，而与愈合方式无关。
这项描述性研究表明，Bio-Oss 胶原增强的人拔牙窝中的骨形成低于未增强的拔牙窝。所有标本均有不同程度的成熟骨形成，而与植入物材料无关，并从根尖区开始。
