Department of Medicine, Division of Infectious Diseases, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1460, Houston, TX, 77030, USA,
Curr Infect Dis Rep. 2011 Aug;13(4):333-42. doi: 10.1007/s11908-011-0187-7.
As life expectancy continues to increase and biotechnology advances, the use of cardiovascular implantable devices will continue to rise. Unfortunately, despite modern medical advances, the infection and mortality rates remain excessively elevated. This article reviews the pathophysiology and general concepts of cardiac device-related infections, including the physical and chemical characteristics of the medical device, host response to the medical device, and the microbiologic virulence factors. Infections of the most commonly utilized cardiovascular implantable devices, including cardiovascular implantable electronic devices, bioprosthetic and mechanical valves, ventricular assist devices, total artificial hearts, and coronary artery stents, are reviewed in detail.
随着预期寿命的持续延长和生物技术的进步，心血管植入设备的使用将继续增加。不幸的是，尽管现代医学取得了进步，但感染率和死亡率仍然过高。本文回顾了与心脏设备相关感染的病理生理学和一般概念，包括医疗器械的物理和化学特性、宿主对医疗器械的反应以及微生物的毒力因素。详细回顾了最常用的心血管植入设备的感染，包括心血管植入式电子设备、生物假体和机械瓣膜、心室辅助设备、全人工心脏和冠状动脉支架。
