Nanomaterial Toxicology Group, Indian Institute of Toxicology Research (CSIR), P.O. Box 80, M. G. Marg, Lucknow 226001, India.
J Biomed Nanotechnol. 2011 Feb;7(1):179-80. doi: 10.1166/jbn.2011.1258.
Fullerenes are fascinating symmetric carbon nanostructures with a potential to bind DNA and proteins. Computational studies were performed to investigate the interaction of fullerenes with the proteins involved in DNA mismatch repair (MMR) pathway. Significant interactions of fullerene with PMS2, RFC3 and PCNA proteins were observed. These findings suggested that fullerene interferes in the human MMR process hence the subsequent disturbance may confer a large increase in spontaneous mutability and a strong predisposition to tumor development.
富勒烯是具有迷人对称性的碳纳米结构，具有结合 DNA 和蛋白质的潜力。进行了计算研究，以研究富勒烯与参与 DNA 错配修复 (MMR) 途径的蛋白质的相互作用。观察到富勒烯与 PMS2、RFC3 和 PCNA 蛋白质的显著相互作用。这些发现表明，富勒烯干扰了人类 MMR 过程，因此随后的干扰可能会导致自发突变率大幅增加，并强烈倾向于肿瘤发展。
