Department of PsychologyNeurosciences Program, Stanford University, Stanford, California.
Ann N Y Acad Sci. 2011 Apr;1224(1):40-62. doi: 10.1111/j.1749-6632.2011.05958.x.
Delineating the functional organization of the prefrontal cortex is central to advancing models of goal-directed cognition. Considerable evidence indicates that specific forms of cognitive control are associated with distinct subregions of the left ventrolateral prefrontal cortex (VLPFC), but less is known about functional specialization within the right VLPFC. We report a functional MRI meta-analysis of two prominent theories of right VLPFC function: stopping of motor responses and reflexive orienting to abrupt perceptual onsets. Along with a broader review of right VLPFC function, extant data indicate that stopping and reflexive orienting similarly recruit the inferior frontal junction (IFJ), suggesting that IFJ supports the detection of behaviorally relevant stimuli. By contrast, other right VLPFC subregions are consistently active during motor inhibition, but not reflexive reorienting tasks, with posterior-VLPFC being active during the updating of action plans and mid-VLPFC responding to decision uncertainty. These results highlight the rich functional heterogeneity that exists within right VLPFC.
明确前额叶皮层的功能组织是推进目标导向认知模型的核心。大量证据表明，特定形式的认知控制与左腹外侧前额叶皮层（VLPFC）的不同子区域相关，但关于右 VLPFC 内的功能特化知之甚少。我们报告了一项关于右 VLPFC 功能的两个突出理论的功能磁共振成像元分析：停止运动反应和对突然知觉起始的反射性定向。除了对右 VLPFC 功能的更广泛回顾外，现有数据表明，停止和反射性定向同样募集下额额连接（IFJ），表明 IFJ 支持对行为相关刺激的检测。相比之下，其他右 VLPFC 子区域在运动抑制期间始终活跃，但在反射性重新定向任务中不活跃，后 VLPFC 在行动计划更新期间活跃，中 VLPFC 对决策不确定性做出反应。这些结果突出了右 VLPFC 内存在的丰富功能异质性。
