Department of Pesticide Chemistry and Toxicology, Alexandria University, Alexandria, Egypt.
Andrologia. 2012 Apr;44(2):116-24. doi: 10.1111/j.1439-0272.2010.01113.x. Epub 2011 Mar 1.
The reproductive toxicity of the insecticide methamidophos was studied in male mice. Adult male mice were treated by gavage with methamidophos at doses of 0, 1, 2 and 3 mg kg(-1) day(-1) for 4 weeks before mating with untreated females. Brain and skeletal muscle acetylcholinesterase activity was inhibited in the middle- and high-treated groups. Methamidophos treatment was associated with a decreased number of live foetuses and an increased number of dead and resorption foetuses at 2 and 3 mg kg(-1) day(-1) treated groups. The per cent morphologically normal spermatozoa were affected in the 2 and 3 mg kg(-1) day(-1) dose groups; however, sperm motility and count were decreased in the same treated groups compared to the control. Histological examination of brain, muscles, testes and epididymis revealed histological abnormalities in a dose-dependent manner. The current study demonstrated adverse effects of male methamidophos exposure on pregnancy outcome with effects on sperm parameters at 2 and 3 mg kg(-1) day(-1) .
本研究旨在探讨杀虫剂甲胺磷对雄性小鼠的生殖毒性。成年雄性小鼠连续灌胃 4 周甲胺磷（剂量分别为 0、1、2 和 3mg/kg·d）后与未处理的雌性小鼠交配。中、高剂量组小鼠脑和骨骼肌乙酰胆碱酯酶活性受到抑制。与对照组相比，2 和 3mg/kg·d 剂量组活胎数减少，死胎和吸收胎数增加。2 和 3mg/kg·d 剂量组的形态正常精子百分率受到影响，而同一处理组的精子活力和计数则降低。脑、肌肉、睾丸和附睾的组织学检查显示，这种组织学异常呈剂量依赖性。本研究表明，雄性接触甲胺磷会对妊娠结局产生不良影响，在 2 和 3mg/kg·d 剂量下还会影响精子参数。
