胰岛素抵抗影响多囊卵巢综合征的中枢阿片活性。
Insulin resistance influences central opioid activity in polycystic ovary syndrome.
机构信息
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
出版信息
Fertil Steril. 2011 Jun 30;95(8):2494-8. doi: 10.1016/j.fertnstert.2011.03.031. Epub 2011 Apr 12.
Abstract
This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.
摘要
这项初步研究描述了胰岛素抵抗与多囊卵巢综合征（PCOS）女性边缘食欲和情绪调节区域的μ-阿片类神经递质传递之间的关系，表明胰岛素-阿片类相互作用可能导致 PCOS 的行为和生殖病理。我们发现，[1]胰岛素抵抗的 PCOS 患者（n = 7）比对照组（n = 5）具有更高的边缘μ-阿片受体可利用性（不可置换结合潜能）；[2]受体可利用性与胰岛素抵抗的严重程度相关；[3]在胰岛素调节治疗后，受体可利用性恢复正常。
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