Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Antimicrob Agents Chemother. 2011 Jun;55(6):3012-4. doi: 10.1128/AAC.00188-11. Epub 2011 Apr 12.
A high rate of resistance (49.5 to 72.7%) to amoxicillin (AMX) was observed in Helicobacter pylori after two or three unsuccessful eradication attempts. Unsuccessful eradication regimens significantly increase resistance to not only clarithromycin (CLR) and metronidazole (MNZ) but also AMX.
在两次或三次根除尝试失败后,观察到幽门螺杆菌对阿莫西林(AMX)的耐药率很高(49.5 至 72.7%)。不成功的根除方案不仅显著增加了克拉霉素(CLR)和甲硝唑(MNZ)的耐药性,也增加了 AMX 的耐药性。