Exercise Physiology and Biochemistry Laboratory, The Department of Kinesiology, Texas Woman's University in Denton, Denton, Texas, USA.
J Strength Cond Res. 2012 Jan;26(1):251-60. doi: 10.1519/JSC.0b013e318218dea3.
The purpose of the study was to determine the efficacy of a low-volume, moderate-intensity bout of resistance exercise (RE) on glucose, insulin, and C-peptide responses during an oral glucose tolerance test (OGTT) in untrained women compared with a bout of high-volume RE of the same intensity. Ten women (age 30.1 ± 9.0 years) were assessed for body composition, maximal oxygen uptake, and 1-repetition maximum (1RM) before completing 3 treatments administered in random order: 1 set of 10 REs (RE1), 3 sets of 10 REs (RE3), and no exercise (C). Twenty-four hours after completing each treatment, an OGTT was performed after an overnight fast. Glucose area under the curve response to an OGTT was reduced after both RE1 (900 ± 113 mmol·L(-1)·min(-1), p = 0.056) and RE3 (827.9 ± 116.3, p = 0.01) compared with C (960.8 ± 152.7 mmol·L(-1)·min(-1)). Additionally, fasting glucose was significantly reduced after RE3 (4.48 ± 0.45 vs. 4.90 ± 0.44 mmol·L(-1), p = 0.01). Insulin sensitivity (IS), as determined from the Cederholm IS index, was improved after RE1 (10.8%) and after RE3 (26.1%). The reductions in insulin and C-peptide areas after RE1 and RE3 were not significantly different from those in the C treatment. In conclusion, greater benefits in glucose regulation appear to occur after higher volumes of RE. However, observed reductions in glucose, insulin, C-peptide areas after RE1 suggest that individuals who may not well tolerate high-volume RE protocols may still benefit from low-volume RE at moderate intensity (65% 1RM).
本研究的目的是确定与相同强度的大运动量 RE 相比，低容量、中等强度的 RE 对未经训练的女性 OGTT 期间的葡萄糖、胰岛素和 C 肽反应的疗效。10 名女性（年龄 30.1±9.0 岁）在完成 3 种随机处理前进行了身体成分、最大摄氧量和 1 次重复最大（1RM）评估：1 组 10 次 RE（RE1）、3 组 10 次 RE（RE3）和无运动（C）。完成每种处理后 24 小时，空腹进行 OGTT。OGTT 后，葡萄糖曲线下面积对 RE1（900±113mmol·L(-1)·min(-1)，p=0.056）和 RE3（827.9±116.3，p=0.01）的反应均降低，与 C（960.8±152.7mmol·L(-1)·min(-1)）相比。此外，RE3 后空腹血糖明显降低（4.48±0.45 与 4.90±0.44mmol·L(-1)，p=0.01）。Cederholm IS 指数测定的胰岛素敏感性（IS）在 RE1 后提高了 10.8%，在 RE3 后提高了 26.1%。RE1 和 RE3 后胰岛素和 C 肽面积的降低与 C 处理无显著差异。总之，更高的 RE 量似乎对血糖调节有更大的益处。然而，RE1 和 RE3 后葡萄糖、胰岛素、C 肽面积的降低表明，可能无法很好耐受高运动量 RE 方案的个体可能仍受益于中等强度（65%1RM）的低运动量 RE。
