Virginia Tech Carilion Research Institute and Department of Psychology Virginia Tech, 2 Riverside Drive, Roanoke, VA 24016, USA.
Psychopharmacology (Berl). 2011 Sep;217(2):177-87. doi: 10.1007/s00213-011-2272-x. Epub 2011 Apr 14.
Intertemporal choice has provided important insights into understanding addiction, predicted drug-dependence status, and outcomes of treatment interventions. However, such analyses have largely been based on the choice of a single commodity available either immediately or later (e.g., money now vs. money later). In real life, important choices for those with addiction depend on making decisions across commodities, such as between drug and non-drug reinforcers. To date, no published study has systematically evaluated intertemporal choice using all combinations of a drug and a non-drug commodity.
In this study, we examine the interaction between intertemporal choice and commodity type in the decision-making process of cocaine-dependent individuals.
This study of 47 treatment-seeking cocaine addicts analyzes intertemporal choices of two commodities (equated amounts of cocaine and money), specifically between cocaine now vs. cocaine later (C-C), money now vs. money later (M-M), cocaine now vs. money later (C-M), and money now vs. cocaine later (M-C).
Cocaine addicts discounted significantly more in the C-C condition than in M-M (P = 0.032), consistent with previous reports. Importantly, the two cross-commodity discounting conditions produced different results. Discounting in C-M was intermediate to the C-C and M-M rates, while the greatest degree of discounting occurred in M-C.
These data indicate that the menu of commodities offered alter discounting rates in intertemporal choice and that the greatest rate is obtained when the drug is the later available commodity. Implications for understanding intertemporal choices and addiction are addressed.
跨期选择为理解成瘾提供了重要的见解,预测了药物依赖状态和治疗干预的结果。然而,此类分析主要基于对即时或以后可用的单一商品的选择(例如,现在的钱与以后的钱)。在现实生活中,对于成瘾者来说,重要的选择取决于对商品的决策,例如药物和非药物奖励之间的决策。迄今为止,尚无发表的研究使用药物和非药物商品的所有组合来系统地评估跨期选择。
在这项研究中,我们检查了可卡因依赖个体决策过程中跨期选择和商品类型之间的相互作用。
这项对 47 名寻求治疗的可卡因成瘾者的研究分析了两种商品的跨期选择(等量可卡因和金钱),特别是现在的可卡因与以后的可卡因(C-C)、现在的钱与以后的钱(M-M)、现在的可卡因与以后的钱(C-M)以及现在的钱与以后的可卡因(M-C)。
可卡因成瘾者在 C-C 条件下的折扣明显高于 M-M 条件(P=0.032),这与之前的报告一致。重要的是,两种跨商品折扣条件产生了不同的结果。C-M 中的折扣率介于 C-C 和 M-M 之间,而最大的折扣率出现在 M-C 中。
这些数据表明,提供的商品菜单改变了跨期选择中的折扣率,并且当药物是以后可用的商品时,获得的折扣率最大。讨论了这些数据对理解跨期选择和成瘾的意义。