Bickel Warren K, Mueller E Terry
Center for Addiction Research, Fred & Louis Dierks Research Laboratories, Psychiatric Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
J Dual Diagn. 2009 Apr 1;5(2):131-138. doi: 10.1080/15504260902869147.
The objective of this article was to propose a novel approach, referred to as the study of trans-disease processes (TDPs), to the neuroscientific study of disease processes in general and to co-morbid diseases in particular. The features of this approach are outlined; one potential TDP-delay discounting, which may help account for the co-morbidity of cigarette smoking and schizophrenia-is explored; and the concept of TDPs is contrasted with the concept of endophenotypes. TDPs have the potential for a variety of positive impacts on science.
本文的目的是提出一种新方法，即跨疾病过程（TDP）研究，用于一般疾病过程特别是共病疾病的神经科学研究。概述了这种方法的特点；探讨了一种潜在的TDP——延迟折扣，它可能有助于解释吸烟与精神分裂症的共病现象；并将TDP的概念与内表型的概念进行了对比。TDP有可能对科学产生各种积极影响。
