Kandolf R
Abteilung Molekulare Pathologie, Institut für Pathologie und Neuropathologie, Universitätsklinikum Tübingen.
Dtsch Med Wochenschr. 2011 Apr;136(16):829-35. doi: 10.1055/s-0031-1275813. Epub 2011 Apr 12.
The diagnosis of myocarditis is still a major challenge in clinical cardiology due to the variety of infectious and non-infectious disease entities. The present review summarizes from the point of view of cardiopathology and infectious medicine morphological and molecular pathological findings in myocardial biopsies of patients with infectious myocarditis, most commonly induced by viral infections, in addition to non-infectious myocarditis mediated by immune processes. A clinical relevant diagnosis of myocarditis is achieved only by integration of clinical, histological, immunohistological and molecular biological findings.
由于感染性和非感染性疾病实体的多样性,心肌炎的诊断仍是临床心脏病学中的一项重大挑战。本综述从心脏病理学和传染病学的角度总结了感染性心肌炎(最常见由病毒感染引起)以及免疫过程介导的非感染性心肌炎患者心肌活检中的形态学和分子病理学发现。心肌炎的临床相关诊断只有通过整合临床、组织学、免疫组织化学和分子生物学发现才能实现。