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用于骨组织工程的双药物递送平台。

Dual drug delivery platforms for bone tissue engineering.

作者信息

V K Anupama Devi, Ray Sarbajit, Arora Udita, Mitra Sunrito, Sionkowska Alina, Jaiswal Amit Kumar

机构信息

Tissue Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), Vellore Institute of Technology (VIT), Vellore, India.

School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, India.

出版信息

Front Bioeng Biotechnol. 2022 Sep 12;10:969843. doi: 10.3389/fbioe.2022.969843. eCollection 2022.

DOI:10.3389/fbioe.2022.969843
PMID:36172012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9511792/
Abstract

The dual delivery platforms used in bone tissue engineering provide supplementary bioactive compounds that include distinct medicines and growth factors thereby aiding enhanced bone regeneration. The delivery of these compounds can be adjusted for a short or prolonged time based on the requirement by altering various parameters of the carrier platform. The platforms thus used are fabricated to mimic the niche of the bone microenvironment, either in the form of porous 3D structures, microspheres, or films. Thus, this review article focuses on the concept of dual drug delivery platform and its importance, classification of various platforms for dual drug delivery specific to bone tissue engineering, and finally highlights the foresight into the future direction of these techniques for better clinical applications.

摘要

骨组织工程中使用的双递送平台可提供包括不同药物和生长因子在内的补充性生物活性化合物，从而有助于增强骨再生。基于需求，通过改变载体平台的各种参数，可以对这些化合物的递送进行短期或长期调整。因此使用的平台被制造成模仿骨微环境的生态位，其形式为多孔3D结构、微球或薄膜。因此，这篇综述文章重点关注双药物递送平台的概念及其重要性、骨组织工程特有的各种双药物递送平台的分类，最后强调了对这些技术未来方向的展望，以实现更好的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/5c65bf8e6bba/fbioe-10-969843-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/f5b4170b3d26/fbioe-10-969843-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/8935c5e42f32/fbioe-10-969843-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/5c65bf8e6bba/fbioe-10-969843-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/4f1a9d3ba906/fbioe-10-969843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/11de5e14766a/fbioe-10-969843-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/8a083e5d3a69/fbioe-10-969843-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/eff31b59a478/fbioe-10-969843-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/117bbd077598/fbioe-10-969843-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/5ffb18ddf793/fbioe-10-969843-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/3269063f55bd/fbioe-10-969843-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/9a28a066a898/fbioe-10-969843-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/5b9bea01d0e5/fbioe-10-969843-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/f5b4170b3d26/fbioe-10-969843-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/5e1f77afe9cb/fbioe-10-969843-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/8935c5e42f32/fbioe-10-969843-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/9511792/5c65bf8e6bba/fbioe-10-969843-g013.jpg

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