Department of Family Medicine, College of Medicine, Korea University, Seoul 152-703, South Korea.
Metabolism. 2011 Sep;60(9):1294-9. doi: 10.1016/j.metabol.2011.01.013. Epub 2011 Apr 12.
The objective of the study was to evaluate the effects of a 10-month lifestyle intervention on the components of the metabolic syndrome (MetSyn) in Koreans with MetSyn as well as on blood concentrations of adiponectin and vaspin. One hundred thirty-eight patients with MetSyn, recruited from a community health care center, were consecutively enrolled in the study; 12 patients dropped of the intervention, leaving 126 subjects (76 men and 50 women; age, 65.3 ± 9.0 years). All participants followed a 10-month lifestyle modification interventional program, including dietary counseling, advice on increasing physical activity, and recommendations to stop or limit smoking and alcohol drinking. Anthropometric and biochemical parameters related to the components of the MetSyn, including blood concentrations of adiponectin and vaspin, were assessed pre- and postintervention. At baseline, adiponectin concentrations were moderately negatively correlated to insulin concentrations and insulin resistance evaluated by the homeostasis model assessment. In response to lifestyle modification, statistically significant changes were found in systolic and diastolic blood pressure, total cholesterol, triglyceride, and insulin concentrations, as well as in homeostasis model assessment of insulin resistance. Adiponectin concentrations postintervention, compared with the preintervention levels, increased (7.2 ± 4.0 vs 6.8 ± 3.9 μg/mL, respectively; P < .05), whereas vaspin concentrations remained unchanged (0.25 ± 0.19 vs 0.26 ± 0.20 ng/mL, respectively; P = .64). A 10-month lifestyle modification program in Korean patients with MetSyn led to favorable changes in metabolic parameters and adiponectin but not vaspin concentrations.
本研究的目的在于评估为期 10 个月的生活方式干预对韩国代谢综合征（MetSyn）患者的代谢综合征组分以及脂联素和 vaspin 血浓度的影响。从社区保健中心招募了 138 例 MetSyn 患者参与本研究，其中 12 例患者中途退出干预，最终有 126 例患者（76 名男性和 50 名女性；年龄，65.3±9.0 岁）完成了整个干预过程。所有参与者均遵循为期 10 个月的生活方式改变干预方案，包括饮食咨询、增加身体活动的建议以及停止或限制吸烟和饮酒的建议。干预前后评估了与代谢综合征组分相关的人体测量学和生化参数，包括脂联素和 vaspin 的血浓度。基线时，脂联素浓度与胰岛素浓度和通过稳态模型评估法评估的胰岛素抵抗呈中度负相关。在生活方式改变的作用下，发现收缩压和舒张压、总胆固醇、甘油三酯和胰岛素浓度以及胰岛素抵抗的稳态模型评估均出现了统计学显著变化。与干预前相比，脂联素浓度在干预后增加（7.2±4.0 与 6.8±3.9μg/mL，分别；P<.05），而 vaspin 浓度则保持不变（0.25±0.19 与 0.26±0.20ng/mL，分别；P=.64）。在韩国 MetSyn 患者中进行为期 10 个月的生活方式改变方案可导致代谢参数和脂联素的改善，但 vaspin 浓度没有变化。
