Department of Obstetrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Oncol Rep. 2011 Jul;26(1):65-71. doi: 10.3892/or.2011.1259. Epub 2011 Apr 13.
Fat accumulation in adipose tissues is a risk factor for the development of human cancers. However, there are no studies describing the fat accumulation in adipose tissue or its distribution in human endometrial cancer. We first examined fat accumulation in adipose tissues separately on CT images of 122 patients with endometrial cancer, and investigated the correlation of these findings with various histological types of endometrial cancers. Fat accumulation in adipose tissues [subcutaneous fat area (SFA) and/or visceral fat areas (VFA)] was strongly correlated with the group of obesity-related biological parameters (weight, body mass index (BMI), waist and body surface area (BSA)) in endometrial cancer. The incidence of type I endometrial cancer was more closely correlated with an increase in obesity-related parameters such as weight (p=0.011), BMI (p=0.006), waist circumference (p=0.038), BSA (p=0.016), SFA (p=0.005), total fat area (TFA) (p=0.006) and total cholesterol (T.Cho) (P=0.010) than type II endometrial cancer. In particular, the SFA was most strongly correlated with obesity-related biological parameters of type I endometrial cancer. The present findings indicate that type I endometrial cancer has a statistically significant increase in obesity-related biological parameters than type II endometrial cancer. We propose that the subcutaneous fat accumulation in adipose tissue is a strong risk factor for developing type I endometrial cancer.
脂肪在脂肪组织中的积累是人类癌症发展的一个风险因素。然而，目前还没有研究描述脂肪在脂肪组织中的积累或其在人类子宫内膜癌中的分布。我们首先在 122 名子宫内膜癌患者的 CT 图像上分别检查了脂肪组织的积累，并研究了这些发现与各种子宫内膜癌组织学类型的相关性。脂肪在脂肪组织中的积累（皮下脂肪面积[SFA]和/或内脏脂肪面积[VFA]）与肥胖相关的生物学参数（体重、体重指数[BMI]、腰围和体表面积[BSA]）呈强烈相关。I 型子宫内膜癌的发病率与体重（p=0.011）、BMI（p=0.006）、腰围（p=0.038）、BSA（p=0.016）、SFA（p=0.005）、总脂肪面积（TFA）（p=0.006）和总胆固醇（T.Cho）（P=0.010）等肥胖相关参数的增加更为密切相关，而 II 型子宫内膜癌则不然。特别是，SFA 与 I 型子宫内膜癌的肥胖相关生物学参数相关性最强。本研究结果表明，I 型子宫内膜癌的肥胖相关生物学参数明显高于 II 型子宫内膜癌。我们提出，脂肪组织中皮下脂肪的积累是发生 I 型子宫内膜癌的一个强烈危险因素。
