Graduate School of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan.
Bioorg Med Chem. 2011 May 1;19(9):2790-6. doi: 10.1016/j.bmc.2011.03.055. Epub 2011 Mar 29.
Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29-nor-cycloartanes, sinocalycanchinensins G and H (7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities.
从夏堇叶片中分离得到了 8 个新的三萜类化合物，包括具有 3,4-裂环-29-降环阿替烷骨架的夏堇辛醇 A-E（1-5）、具有新型 2,3-裂环-29-降环阿替烷骨架的夏堇辛醇 F（6）和 29-降环阿替烷、夏堇辛醇 G 和 H（7 和 8）。基于光谱检查，阐明了它们的结构。还评估了分离得到的新三萜类化合物对包括多药耐药（MDR）癌细胞系在内的一系列人类癌细胞系的细胞毒性。尽管所有化合物均表现出中等或无细胞毒性，但化合物 5 在秋水仙素存在的情况下对 MDR KB 细胞显示出增强的细胞毒性。
