1st Academic ENT Department, AHEPA Hospital, Thessaloniki, Greece.
Otolaryngol Head Neck Surg. 2011 Jul;145(1):125-30. doi: 10.1177/0194599811401206.
The aim of this prospective study was to audiologically evaluate consecutive glaucoma patients with or without exfoliation.
Prospective study.
Glaucoma Unit and Audiology Department at a university hospital.
Consecutive subjects with exfoliative glaucoma (XFG) or primary open-angle glaucoma (POAG) aged between 50 and 70 years were enrolled. Auditory thresholds at 0.5, 1.0, 2.0, 4.0, and 8.0 Hz were measured bilaterally. Cochlear activity was assessed by recording distortion product otoacoustic emissions (DPOEs). Functional changes in the retrocochlear auditory pathway were evaluated by auditory brainstem responses (ABRs).
One hundred and ten patients with XFG and 85 patients with POAG who presented in a glaucoma clinic were investigated. The mean age of study patients was 66.2 ± 5.6 years; range, 50-70 years). The odds of pathologic ABR central transmission time (interpeak latencies I-III, III-V, and I-V and waves I, III, and V) were 4.34 times higher in patients with XFG than in patients with POAG (95% confidence interval [CI], 2.22-8.49; P < .001). This significant association remained after adjusting for sex and age (odds ratio [OR] 4.12; 95% CI, 2.07-8.22; P < .001). Furthermore, the odds of ABR remained significantly higher in patients with XFG than in patients with POAG (OR 4.36; 95% CI, 2.10-9.06; P < .001) after controlling for systemic diseases (arterial hypertension, coronary heart disease, high cholesterol, and stroke).
In the first study to compare XFG and POAG monitoring of the peripheral and central auditory pathway, it has been documented that XFG patients show a greater prevalence of retrocochlear pathology.
本前瞻性研究旨在对伴有或不伴有剥脱综合征的连续青光眼患者进行听力评估。
前瞻性研究。
大学医院的青光眼科和听力科。
纳入年龄在 50 至 70 岁之间的连续剥脱性青光眼（XFG）或原发性开角型青光眼（POAG）患者。分别测量双侧 0.5、1.0、2.0、4.0 和 8.0 Hz 的听阈。通过记录畸变产物耳声发射（DPOAE）评估耳蜗活动。通过听脑干反应（ABR）评估耳蜗后听觉通路的功能变化。
对 110 例 XFG 患者和 85 例 POAG 患者进行了研究，这些患者在青光眼门诊就诊。研究患者的平均年龄为 66.2 ± 5.6 岁；范围为 50-70 岁）。与 POAG 患者相比，XFG 患者的 ABR 中央传导时间（峰间潜伏期 I-III、III-V 和 I-V 及波 I、III 和 V）异常的可能性高 4.34 倍（95%置信区间 [CI]，2.22-8.49；P<.001）。在调整性别和年龄后，这种显著相关性仍然存在（比值比 [OR] 4.12；95%CI，2.07-8.22；P<.001）。此外，在控制全身疾病（动脉高血压、冠心病、高胆固醇血症和中风）后，XFG 患者的 ABR 异常可能性仍显著高于 POAG 患者（OR 4.36；95%CI，2.10-9.06；P<.001）。
在首次比较 XFG 和 POAG 监测外周和中枢听觉通路的研究中，已经证明 XFG 患者的耳蜗后病理更为常见。
