Pferdeklinik Tillysburg, Bruck bei Hausleiten 11, 4490 St Florian, Austria.
Vet Rec. 2011 Feb 19;168(7):187. doi: 10.1136/vr.c5430. Epub 2011 Feb 11.
Based on the anecdotally reported eradication of a sarcoid using aciclovir cream, the curative potential of this ointment was investigated in 22 sarcoid-affected horses referred to the Equine Clinic Tillysburg, Austria, between 2006 and 2009. Sarcoid disease was diagnosed by clinical examination and bovine papillomavirus types 1 and 2 from intact skin and tumour tissue. As nine horses had more than one lesion, a total of 47 sarcoids were treated by daily topical application of aciclovir 5 per cent cream for a period of two to six months; in four horses, surgical tumour ablation was performed before treatment. Disease parameters, including the tumour type, number, location and size, were recorded before and after aciclovir therapy. All 47 (100 per cent) of the sarcoids responded to treatment, with complete tumour regression observed for 32 (68 per cent) lesions and no recurrences reported thus far. Incomplete resolution was observed for 15 (32 per cent) lesions, probably due to their thickness. Aciclovir is proposed to be routinely used for the treatment of mild-type sarcoids and as an adjuvant therapeutic agent in combination with surgery.
基于使用阿昔洛韦乳膏成功消除一例结节病的个案报告，本研究于 2006 年至 2009 年期间，在奥地利 Tillysburg 的马科诊所，对 22 匹患有结节病的马进行了该乳膏的疗效研究。通过临床检查和牛乳头瘤病毒 1 型和 2 型，对完整皮肤和肿瘤组织进行了结节病的诊断。由于 9 匹马有一个以上的病变，因此共有 47 个结节病采用 5%阿昔洛韦乳膏进行每日局部应用，治疗期为 2 至 6 个月；在 4 匹马中，在治疗前进行了手术肿瘤消融。在阿昔洛韦治疗前后，记录了疾病参数，包括肿瘤类型、数量、位置和大小。所有 47 个（100%）结节病均对治疗有反应，32 个（68%）病变完全消退，迄今为止没有复发报告。15 个（32%）病变的消退不完全，可能是由于病变较厚。建议将阿昔洛韦常规用于治疗轻度结节病，并作为手术的辅助治疗药物。
