Haspeslagh Maarten, Jordana Garcia Mireia, Vlaminck Lieven E M, Martens Ann M
Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
BMC Vet Res. 2017 Oct 6;13(1):296. doi: 10.1186/s12917-017-1215-0.
Previous studies mention the use of topical acyclovir for the treatment of equine sarcoids. Success rates vary and since the bovine papillomavirus (BPV) lacks the presence of a kinase necessary to activate acyclovir, there is no proof of its activity against equine sarcoids.
Twenty-four equine sarcoids were topically treated with acyclovir cream and 25 with a placebo. Both creams were applied twice daily during 6 months. Before the start of the treatment and further on a monthly basis, photographs and swabs were obtained. On the photographs, sarcoid diameter and surface area were measured and verrucosity of the tumours was quantified using a visual analog scale (VAS). The swabs were analysed by PCR for the presence of BPV DNA and positivity rates were calculated as the number of positive swabs divided by the total number of swabs for each treatment group at each time point. Success rates were not significantly different between both treatment groups. There was also no significant effect of treatment on sarcoid diameter, surface area or VAS score. For the swabs, a significantly higher BPV positivity rate was found for acyclovir treated tumours compared to placebo treated sarcoids only after 1 month of treatment and not at other time points.
None of the results indicate that treatment with acyclovir yields any better results compared to placebo treatment.
先前的研究提到使用局部用阿昔洛韦治疗马的肉瘤样病。成功率各不相同，并且由于牛乳头瘤病毒（BPV）缺乏激活阿昔洛韦所需的激酶，因此没有证据表明其对马的肉瘤样病有活性。
24个马的肉瘤样病用阿昔洛韦乳膏进行局部治疗，25个用安慰剂治疗。两种乳膏均每天涂抹两次，持续6个月。在治疗开始前及之后每月一次，获取照片和拭子。在照片上，测量肉瘤的直径和表面积，并使用视觉模拟量表（VAS）对肿瘤的疣状程度进行量化。通过PCR分析拭子中BPV DNA的存在情况，并计算阳性率，即每个治疗组在每个时间点阳性拭子的数量除以拭子总数。两个治疗组之间的成功率没有显著差异。治疗对肉瘤的直径、表面积或VAS评分也没有显著影响。对于拭子，仅在治疗1个月后，与安慰剂治疗的肉瘤相比，阿昔洛韦治疗的肿瘤的BPV阳性率显著更高，其他时间点则没有。
没有结果表明与安慰剂治疗相比，阿昔洛韦治疗能产生更好的效果。
