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学习促进 CA3 苔藓纤维和联合突触的突触可塑性揭示了在信息处理中不同的作用。

Learning-facilitated synaptic plasticity at CA3 mossy fiber and commissural-associational synapses reveals different roles in information processing.

机构信息

Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Universitaetsstrasse 150, 44780 Bochum, Germany.

出版信息

Cereb Cortex. 2011 Nov;21(11):2442-9. doi: 10.1093/cercor/bhq271. Epub 2011 Apr 14.

DOI:10.1093/cercor/bhq271
PMID:21493717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3183418/
Abstract

Subregion-dependent differences in the role of the hippocampus in information processing exist. Recently, it has emerged that a special relationship exists between the expression of persistent forms of synaptic plasticity in hippocampal subregions and the encoding of different types of spatial information. Little is known about this type of information processing at CA3 synapses. We report that in freely behaving rats, long-term potentiation (LTP) is facilitated at both mossy fiber (mf)-CA3 and commissural-associational (AC)-CA3 synapses by exploration of a novel (empty) environment. Exploration of large spatial landmarks facilitates long-term depression (LTD) at mf-CA3 synapses and impairs synaptic depression at AC-CA3 synapses. Novel exploration of small environmental features does not facilitate LTD at mf synapses but facilitates persistent LTD at AC synapses. Thus, depending on the quality of the information synaptic plasticity at AC-CA3 and mf-CA3 synapses is differentially modulated. These data suggest that expression of LTP as a result of environmental change is a common property of hippocampal synapses. However, LTD at mf synapses or AC synapses may subserve distinct and separate functions within the CA3 region.

摘要

海马体在信息处理中的作用存在亚区依赖性差异。最近，海马体亚区中持续形式的突触可塑性的表达与不同类型的空间信息编码之间存在特殊关系。关于 CA3 突触的这种信息处理方式知之甚少。我们报告在自由活动的大鼠中，通过探索新的（空的）环境，增强了苔藓纤维（mf）-CA3 和联合联络（AC）-CA3 突触的长时程增强（LTP）。探索大的空间地标促进 mf-CA3 突触的长时程抑制（LTD），并损害 AC-CA3 突触的突触抑制。对小环境特征的新探索不会促进 mf 突触的 LTD，但会促进 AC 突触的持续 LTD。因此，取决于信息的质量，AC-CA3 和 mf-CA3 突触的突触可塑性会得到不同的调节。这些数据表明，环境变化导致的 LTP 表达是海马体突触的共同特性。然而，mf 突触或 AC 突触的 LTD 可能在 CA3 区域内发挥不同的、独立的功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/ebf44b8083ee/cercorbhq271f10_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/417a9a2212f2/cercorbhq271f01_ht.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/efa9ea06990b/cercorbhq271f03_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/2cd1a67f4478/cercorbhq271f04_ht.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/42e78279a1a3/cercorbhq271f08_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/e83cfd459d40/cercorbhq271f09_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/ebf44b8083ee/cercorbhq271f10_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/417a9a2212f2/cercorbhq271f01_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/0a2b675f359b/cercorbhq271f02_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/efa9ea06990b/cercorbhq271f03_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/2cd1a67f4478/cercorbhq271f04_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/d347c3c48da0/cercorbhq271f05_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/3b2ff39f60fd/cercorbhq271f06_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/d6c2026928d8/cercorbhq271f07_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/42e78279a1a3/cercorbhq271f08_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/e83cfd459d40/cercorbhq271f09_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/3183418/ebf44b8083ee/cercorbhq271f10_ht.jpg

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