An Analysis of All the Relevant Facts and Arguments Indicates that Enzyme Catalysis Does Not Involve Large Contributions from Nuclear Tunneling.
作者信息
Kamerlin Shina C L, Warshel Arieh
机构信息
Department of Chemistry, University of Southern California, 3620 McClintock Ave., Los Angeles CA-90089, USA.
出版信息
J Phys Org Chem. 2010 Jul;23(7):677-684. doi: 10.1002/poc.1620.
Abstract
摘要
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An Analysis of All the Relevant Facts and Arguments Indicates that Enzyme Catalysis Does Not Involve Large Contributions from Nuclear Tunneling.对所有相关事实和论据的分析表明，酶催化并不涉及核隧穿的重大贡献。
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Enzymology takes a quantum leap forward.酶学取得了巨大的飞跃。
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On the relationship between folding and chemical landscapes in enzyme catalysis.关于酶催化中折叠与化学景观之间的关系。
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13877-82. doi: 10.1073/pnas.0803405105. Epub 2008 Sep 8.
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On the interpretation of the observed linear free energy relationship in phosphate hydrolysis: a thorough computational study of phosphate diester hydrolysis in solution.关于磷酸水解中观察到的线性自由能关系的解释：溶液中磷酸二酯水解的全面计算研究。
Biochemistry. 2008 Mar 25;47(12):3725-35. doi: 10.1021/bi702106m. Epub 2008 Feb 29.
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Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.酶的结构与动力学影响氢隧穿：大豆脂氧合酶-1中一个远端侧链（I553）的影响
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1146-51. doi: 10.1073/pnas.0710643105. Epub 2008 Jan 23.
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J Phys Chem B. 2007 Jul 12;111(27):7852-61. doi: 10.1021/jp070938f. Epub 2007 Jun 16.
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A new paradigm for electrostatic catalysis of radical reactions in vitamin B12 enzymes.维生素B12酶中自由基反应静电催化的新范式。
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The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies.二氢叶酸还原酶及其突变体的催化作用由重组能决定。
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Electrostatic contributions to binding of transition state analogues can be very different from the corresponding contributions to catalysis: phenolates binding to the oxyanion hole of ketosteroid isomerase.过渡态类似物结合过程中的静电作用可能与相应的催化作用贡献有很大不同：酚盐与酮甾体异构酶的氧负离子洞结合。
Biochemistry. 2007 Feb 13;46(6):1466-76. doi: 10.1021/bi061752u.
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