Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy.
PLoS One. 2011 Apr 8;6(4):e18647. doi: 10.1371/journal.pone.0018647.
Although prostatitis syndrome (PS) and irritable bowel syndrome (IBS) are common disorders, information on the prevalence of IBS in infertile patients with PS is relatively scanty. Therefore, this study was undertaken to estimate the frequency of PS and IBS and to evaluate the prevalence of the various diagnostic categories of prostatitis.
METHODOLOGY/PRINCIPAL FINDINGS: This study enrolled 152 patients with PS, diagnosed by the NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) in an andrological setting, and 204 patients with IBS, diagnosed according to the Rome III diagnostic criteria in a gastroenterological setting. The patients with PS were asked to fulfill the Rome III questionnaire for IBS, whereas patients with IBS were asked to complete the NIH-CPSI. The simultaneous presence of PS and IBS was observed in 30.2% and 31.8% of the patients screened by andrologists and gastroenterologists, respectively. Altogether, 111 patients had PS plus IBS (31.2%). They had a total NIH-CPSI and pain subscale scores significantly higher than patients with PS alone. Gastrointestinal symptoms in patients with PS plus IBS were similar to those reported by patients with IBS alone and significantly greater in patients with PS alone. Patients with PS plus IBS had a significantly higher frequency of chronic bacterial prostatitis (category II) and lower of non-inflammatory prostatitis (category IIIB), compared to patients with PS alone. The frequency of inflammatory prostatitis (category IIIA) resulted similar.
CONCLUSIONS/SIGNIFICANCE: Prostatitis syndromes and IBS are frequently associated in patients with PS- or IBS-related symptoms. These patients have an increased prevalence of chronic bacterial and non-inflammatory prostatitis.
前列腺炎综合征（PS）和肠易激综合征（IBS）虽然是常见疾病，但有关 PS 不孕患者中 IBS 患病率的信息相对较少。因此，本研究旨在评估 PS 和 IBS 的频率，并评估前列腺炎的各种诊断类别。
方法/主要发现：本研究纳入了 152 例在男科环境下根据 NIH-慢性前列腺炎症状指数（NIH-CPSI）诊断为 PS 的患者和 204 例在胃肠科环境下根据罗马 III 诊断标准诊断为 IBS 的患者。要求 PS 患者填写罗马 III 型 IBS 问卷，而 IBS 患者则填写 NIH-CPSI。通过男科医生和胃肠科医生筛查，分别观察到 30.2%和 31.8%的患者同时存在 PS 和 IBS。共有 111 例患者同时患有 PS 和 IBS（31.2%）。他们的 NIH-CPSI 和疼痛子量表评分明显高于仅患有 PS 的患者。同时患有 PS 和 IBS 的患者的胃肠道症状与仅患有 IBS 的患者报告的症状相似，而仅患有 PS 的患者的胃肠道症状则明显更大。与仅患有 PS 的患者相比，同时患有 PS 和 IBS 的患者慢性细菌性前列腺炎（II 类）的发生率明显更高，而非炎性前列腺炎（IIIB 类）的发生率较低。炎症性前列腺炎（IIIA 类）的发生率则相似。
结论/意义：前列腺炎综合征和 IBS 常与 PS 或 IBS 相关症状的患者相关。这些患者慢性细菌性和非炎性前列腺炎的患病率增加。
