Department of Chemistry, National University of Singapore, 3 Science Drive34, Singapore 117543.
Chem Commun (Camb). 2011 May 28;47(20):5664-5670. doi: 10.1039/c1cc11464f. Epub 2011 Apr 14.
The turn of the century witnessed the development of small molecule, protein, cell and tissue microarrays, heralding a new era of discovery-driven research using a host of different chemical libraries, biomolecules and tissue types. This highlight takes stock of this first decade of small molecule microarrays (SMMs) and describes how the technology has matured into a robust screening platform. We also highlight the many interesting and unique applications appearing using small molecule microarrays, in order to project forward to possible areas in which SMMs could contribute further to over the next five to ten years.
本世纪初见证了小分子、蛋白质、细胞和组织微阵列的发展，预示着使用各种不同的化学文库、生物分子和组织类型进行以发现为导向的研究的新时代的到来。这一重点介绍了小分子微阵列 (SMM) 的第一个十年，并描述了该技术如何发展成为一个强大的筛选平台。我们还强调了使用小分子微阵列出现的许多有趣和独特的应用，以便预测在未来五到十年内 SMM 可能会有更多贡献的可能领域。
