替考霉素与其他抗生素的体外活性比较。
In vitro activity of teichomycin compared with those of other antibiotics.
作者信息
Neu H C, Labthavikul P
出版信息
Antimicrob Agents Chemother. 1983 Sep;24(3):425-8. doi: 10.1128/AAC.24.3.425.
Abstract
The glycopeptide antibiotic teichomycin had in vitro activity comparable to that of vancomycin against most gram-positive species, and it inhibited methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. It was twofold more active against many S. aureus and S. epidermidis isolates than was vancomycin. Teichomycin had activity comparable to that of vancomycin against Listeria monocytogenes and Streptococcus faecalis. It was generally more active against streptococci than was vancomycin. There were no major differences between minimal inhibitory concentrations and minimal bactericidal concentrations of these drugs. Teichomycin acted synergistically with gentamicin against some bacteria.
摘要
糖肽类抗生素替考拉宁对大多数革兰氏阳性菌具有与万古霉素相当的体外活性，并且它能抑制耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌。它对许多金黄色葡萄球菌和表皮葡萄球菌分离株的活性比万古霉素高两倍。替考拉宁对单核细胞增生李斯特菌和粪肠球菌具有与万古霉素相当的活性。它对链球菌的活性通常比万古霉素更高。这些药物的最低抑菌浓度和最低杀菌浓度之间没有重大差异。替考拉宁与庆大霉素对某些细菌具有协同作用。
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