吲哚菁绿作为一种近红外荧光对比剂在影像引导肿瘤外科手术中的临床应用。
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery.
机构信息
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
J Surg Oncol. 2011 Sep 1;104(3):323-32. doi: 10.1002/jso.21943. Epub 2011 Apr 14.
Abstract
Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.
摘要
近红外（NIR）荧光光学成像为普通和肿瘤外科提供了新的前景。吲哚菁绿（ICG）目前在与癌症相关的 NIR 荧光手术中用于三种适应症：前哨淋巴结（SLN）绘图、术中识别实体瘤和重建手术中的血管造影。因此，了解其优缺点非常重要。尽管 ICG 是非靶向和非共轭的，但它似乎为更广泛地应用 NIR 荧光引导手术奠定了基础。
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