University of Limoges, IFR 145 GEIST, Institute of Neuroepidemiology and Tropical Neurology, EA3174 NETEC, Faculty of Medicine-2 rue du Dr Marcland, 87025 Limoges, France.
Atherosclerosis. 2011 Jun;216(2):251-7. doi: 10.1016/j.atherosclerosis.2011.03.024. Epub 2011 Mar 25.
To investigate the association between a low ankle-brachial index (ABI) and several grades of cognitive disorders: cognitive impairment, dementia and Alzheimer's disease (AD), in the general population.
We performed a systematic review of the literature, including all prospective, longitudinal or cross-sectional studies assessing both peripheral artery disease (PAD), defined by a low ABI, and cognitive function.
12 publications were included in this review, of whom 6 reported cross-sectional analysis and 6 reported longitudinal analysis. All except one reported a significant association between a low ankle-brachial index and cognitive impairment, dementia or AD. Beyond cognitive impairment, patients with PAD are at an increased risk to develop dementia or Alzheimer's disease.
In this review, we confirm that a low (<0.90) ABI can be considered as a marker of cognitive impairment and dementia. ABI provides independent and supplemental information on subject's susceptibility to develop cognitive disorders, along its usefulness to predict cardiovascular diseases (CVD). Given its availability, easiness, safety to patients and low cost, the ABI could be useful in clinical practice and research in the field of cognitive diseases.
探讨在普通人群中，低踝臂指数（ABI）与几种认知障碍程度（认知障碍、痴呆和阿尔茨海默病（AD））之间的关联。
我们对文献进行了系统回顾，包括所有评估外周动脉疾病（PAD）的前瞻性、纵向或横断面研究，PAD 通过低 ABI 来定义，并评估认知功能。
本综述共纳入 12 篇文献，其中 6 篇报告了横断面分析，6 篇报告了纵向分析。除 1 篇外，其余所有文献均报告低踝臂指数与认知障碍、痴呆或 AD 之间存在显著相关性。除认知障碍外，PAD 患者发生痴呆或阿尔茨海默病的风险增加。
在本综述中，我们证实低（<0.90）ABI 可被视为认知障碍和痴呆的标志物。ABI 可提供有关个体发生认知障碍易感性的独立和补充信息，以及预测心血管疾病（CVD）的作用。鉴于其可用性、简便性、对患者的安全性和低成本，ABI 可能有助于认知疾病领域的临床实践和研究。
