Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA.
Trends Endocrinol Metab. 2011 Jun;22(6):241-8. doi: 10.1016/j.tem.2011.03.004. Epub 2011 Apr 15.
Hepatitis C virus (HCV) infects approximately 3% of the world's population, establishing a lifelong infection in the majority of cases. The life cycle of HCV is closely tied to the lipid metabolism of liver cells, and lipid droplets have emerged as crucial intracellular organelles that support persistent propagation of viral infection. In this review, we examine recent advances in our understanding of how HCV usurps intracellular lipids to propagate, and highlight unique opportunities for therapeutic intervention.
丙型肝炎病毒 (HCV) 感染了全球约 3%的人口，在大多数情况下导致终身感染。HCV 的生命周期与肝细胞的脂质代谢密切相关，脂滴已成为支持病毒持续感染的关键细胞内细胞器。在这篇综述中，我们探讨了近年来对 HCV 劫持细胞内脂质进行复制的机制的理解进展，并强调了治疗干预的独特机会。
