丙型肝炎病毒复制与细胞内脂质之间的独特联系。
Unique ties between hepatitis C virus replication and intracellular lipids.
机构信息
Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA.
出版信息
Trends Endocrinol Metab. 2011 Jun;22(6):241-8. doi: 10.1016/j.tem.2011.03.004. Epub 2011 Apr 15.
Abstract
Hepatitis C virus (HCV) infects approximately 3% of the world's population, establishing a lifelong infection in the majority of cases. The life cycle of HCV is closely tied to the lipid metabolism of liver cells, and lipid droplets have emerged as crucial intracellular organelles that support persistent propagation of viral infection. In this review, we examine recent advances in our understanding of how HCV usurps intracellular lipids to propagate, and highlight unique opportunities for therapeutic intervention.
摘要
丙型肝炎病毒 (HCV) 感染了全球约 3%的人口，在大多数情况下导致终身感染。HCV 的生命周期与肝细胞的脂质代谢密切相关，脂滴已成为支持病毒持续感染的关键细胞内细胞器。在这篇综述中，我们探讨了近年来对 HCV 劫持细胞内脂质进行复制的机制的理解进展，并强调了治疗干预的独特机会。
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本文引用的文献
1
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Cell Host Microbe. 2011 Jan 20;9(1):32-45. doi: 10.1016/j.chom.2010.12.002.
2
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.丙型肝炎病毒非结构蛋白 2 的结构和功能研究揭示了其作为病毒组装组织者的关键作用。
PLoS Pathog. 2010 Dec 16;6(12):e1001233. doi: 10.1371/journal.ppat.1001233.
3
Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.丙型肝炎病毒 NS2 通过与 E1-E2 糖蛋白和 NS3-NS4A 酶复合物的物理相互作用来协调病毒粒子的组装。
J Virol. 2011 Feb;85(4):1706-17. doi: 10.1128/JVI.02268-10. Epub 2010 Dec 8.
4
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J Biol Chem. 2011 Jan 28;286(4):3018-32. doi: 10.1074/jbc.M110.175018. Epub 2010 Nov 5.
5
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J Virol. 2011 Jan;85(1):86-97. doi: 10.1128/JVI.01070-10. Epub 2010 Oct 20.
6
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8
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9
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J Gen Virol. 2011 Jan;92(Pt 1):101-11. doi: 10.1099/vir.0.023325-0. Epub 2010 Sep 29.
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