Schmidt-Ukaj Silvana, Brunthaler Rene, Gumpenberger Michaela
Service for Birds and Reptiles, Clinical Centre for Small Animals, University of Veterinary Medicine, Vienna, Austria.
Institute for Pathology, University of Veterinary Medicine, Vienna, Austria.
BMC Vet Res. 2024 Dec 5;20(1):552. doi: 10.1186/s12917-024-04368-2.
Malignant dysgerminomas are infrequently reported ovarian neoplasms in animals, especially in exotic pets (non-traditional companion animals [NTCAs]). In the few published case reports on reptilian species, examples are primarily postmortem without antemortem (clinical) assessment.
An adult, 13-year-old, spayed female inland bearded dragon (Pogona vitticeps) presented with lethargy, a right-sided head tilt, unilateral exophthalmos and ventrotemporal strabismus on the right eye. On examination, a palpable mass (approximately 3.5 cm in diameter) was detected within the mid coelomic cavity. Computed tomography revealed a retrobulbar swelling and lytic bone lesions affecting the right frontal bone and several vertebrae (T11, T13, and T14). Multiple nodules of soft tissue opacity were also detected within the lungs, liver, and coelomic fat bodies. Haematology revealed leukocytosis with heterophilia and toxic granulation of heterophils. On the basis of these results, differential diagnoses included disseminated abscesses, granulomas (e.g., due to mycobacteriosis) and neoplasms. The lizard was subsequently euthanized due to end-stage disease and a poor prognosis. Postmortem gross examination and histopathology revealed a primary ovarian dysgerminoma with evidence of widespread metastasis as well as localized tissue destruction affecting the right retrobulbar space and frontal bone, the spinal column, the lungs, the liver, and both coelomic fat bodies.
This report describes a case of malignant dysgerminoma with widespread intraosseous and visceral metastases in a captive inland bearded dragon (Pogona vitticeps).
恶性无性细胞瘤是动物中报道较少的卵巢肿瘤，尤其是在 exotic pets（非传统伴侣动物 [NTCAs]）中。在少数已发表的关于爬行动物物种的病例报告中，病例主要是死后检查，没有生前（临床）评估。
一只 13 岁的成年去势雌性内陆鬃狮蜥（鬃狮蜥）出现嗜睡、右侧头部倾斜、右眼单侧眼球突出和颞下斜视。检查时，在中腹腔内发现一个可触及的肿块（直径约 3.5 厘米）。计算机断层扫描显示球后肿胀和溶骨性骨病变，影响右侧额骨和几个椎骨（T11、T13 和 T14）。在肺、肝和腹腔脂肪体中也检测到多个软组织密度结节。血液学检查显示白细胞增多，伴有嗜异性粒细胞增多和嗜异性粒细胞毒性颗粒。基于这些结果，鉴别诊断包括播散性脓肿、肉芽肿（例如由于分枝杆菌病）和肿瘤。这只蜥蜴随后因疾病晚期和预后不良而被安乐死。死后大体检查和组织病理学检查显示原发性卵巢无性细胞瘤，有广泛转移的证据，以及影响右侧球后间隙和额骨、脊柱、肺、肝和两个腹腔脂肪体的局部组织破坏。
本报告描述了一例圈养内陆鬃狮蜥（鬃狮蜥）发生的伴有广泛骨内和内脏转移的恶性无性细胞瘤病例。
