Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
Nutrition. 2011 Sep;27(9):863-7. doi: 10.1016/j.nut.2010.12.011. Epub 2011 Apr 17.
High consumption of ω-3 polyunsaturated fatty acids (PUFAs) has been associated with lower plasma homocystine (Hcy) levels, but intervention studies in humans have been inconclusive. The objective was to systematically evaluate the effects of ω-3 PUFA supplementation on plasma Hcy levels.
A comprehensive search of Medline, EMBASE, the Cochrane Clinical Trials Registry, and bibliographies of relevant articles published from 1966 through September 2010 was undertaken. All randomized, placebo-controlled trials that compared ω-3 PUFA supplementation with placebo were included. Two investigators performed data extraction and quality scoring independently, with discrepancies resolved by consensus.
Eleven trials including 702 subjects were analyzed. The outcomes studied were plasma Hcy level. Eleven randomized, placebo-controlled trials were included in this meta-analysis. Supplementation with ω-3 PUFAs was associated with a significant decrease in plasma Hcy level (weighted mean difference -1.59 μmol/L, 95% confidence interval -2.34 to -0.83) compared with control subjects.
This meta-analysis suggested that ω-3 PUFA supplementation can decrease plasma Hcy levels. The implications of these findings remain to be elucidated.
大量摄入 ω-3 多不饱和脂肪酸（PUFAs）与降低血浆同型半胱氨酸（Hcy）水平有关，但人体干预研究尚无定论。本研究旨在系统评估 ω-3 PUFAs 补充对血浆 Hcy 水平的影响。
综合检索 Medline、EMBASE、Cochrane 临床试验注册中心和 1966 年至 2010 年 9 月发表的相关文章的参考文献。纳入所有比较 ω-3 PUFAs 补充剂与安慰剂的随机、安慰剂对照试验。两名研究者独立进行数据提取和质量评分，有分歧时通过共识解决。
纳入 702 例患者的 11 项试验进行了分析。研究的结局为血浆 Hcy 水平。本荟萃分析纳入了 11 项随机、安慰剂对照试验。与对照组相比，ω-3 PUFAs 补充剂可显著降低血浆 Hcy 水平（加权均数差-1.59 μmol/L，95%置信区间-2.34 至-0.83）。
本荟萃分析表明，ω-3 PUFAs 补充剂可降低血浆 Hcy 水平。这些发现的意义仍有待阐明。
