疫苗低应答者和无应答者的乙肝疫苗接种策略：数量还是质量的问题？
Hepatitis B vaccination strategy in vaccine low and non-responders: a matter of quantity of quality?
作者信息
Roukens Anna H, Visser Leo G
机构信息
Department of Infectious Diseases, Leiden University Medical Centre, Leiden, the Netherlands.
出版信息
Hum Vaccin. 2011 Jun;7(6):654-7. doi: 10.4161/hv.7.6.14986. Epub 2011 Jun 1.
Hepatitis B virus infection can lead to chronic infection and liver failure. Transmission of the virus is preventable though vaccination. Unfortunately, 5-10% of healthy individuals and 40-50% of haemodialysis patients do not develop an adequate immune response against the vaccine. In this commentary we focus on the possible biological mechanisms of hepatitis B vaccine unresponsiveness, and give practical advice to overcome this unresponsiveness.
乙型肝炎病毒感染可导致慢性感染和肝衰竭。通过接种疫苗可预防该病毒的传播。不幸的是，5%-10%的健康个体和40%-50%的血液透析患者对疫苗未产生足够的免疫反应。在本评论中，我们重点关注乙型肝炎疫苗无反应性的可能生物学机制，并给出克服这种无反应性的实用建议。
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