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Correlation of transplacental and maternal pharmacokinetics of retinoids during organogenesis with teratogenicity.

作者信息

Nau H

出版信息

Methods Enzymol. 1990;190:437-48. doi: 10.1016/0076-6879(90)90050-b.

DOI:10.1016/0076-6879(90)90050-b
PMID:2150873
Abstract
摘要

相似文献

1
Correlation of transplacental and maternal pharmacokinetics of retinoids during organogenesis with teratogenicity.器官形成期维甲酸经胎盘和母体的药代动力学与致畸性的相关性。
Methods Enzymol. 1990;190:437-48. doi: 10.1016/0076-6879(90)90050-b.
2
Transplacental pharmacokinetics of teratogenic doses of etretinate and other aromatic retinoids in mice.致畸剂量的依曲替酯及其他芳香维甲酸在小鼠体内的经胎盘药代动力学
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3
Acitretin (Neotigason). A review of pharmacokinetics and teratogenicity and hypothesis on metabolic pathways.阿维A（新银屑灵）。药代动力学与致畸性综述及代谢途径假说
Pharm Weekbl Sci. 1992 Apr 24;14(2):33-7. doi: 10.1007/BF01980479.
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Teratogenicity of the 13-cis and all-trans-isomers of the aromatic retinoid etretin: correlation to transplacental pharmacokinetics in mice during organogenesis after a single oral dose.芳香维甲酸依曲替酯的13 - 顺式和全反式异构体的致畸性：单次口服给药后器官形成期小鼠经胎盘药代动力学的相关性
Teratology. 1990 Jun;41(6):707-16. doi: 10.1002/tera.1420410607.
5
Conceptional biotransformation of microinjected retinoids. Correlations with dysmorphogenic activities.显微注射类视黄醇的概念性生物转化。与致畸活性的相关性。
Ann N Y Acad Sci. 1993 Mar 15;678:338-40. doi: 10.1111/j.1749-6632.1993.tb26138.x.
6
Teratogenicity of steady-state concentrations of etretinate and metabolite acitretin maintained in maternal plasma and embryo by intragastric infusion during organogenesis in the mouse: a possible model for the extended elimination phase in human therapy.通过在小鼠器官形成期经胃灌注维持母体血浆和胚胎中阿维A酯及其代谢产物阿维A的稳态浓度的致畸性：人类治疗中延长消除期的一种可能模型。
Dev Pharmacol Ther. 1990;15(1):45-51. doi: 10.1159/000457618.
7
Transplacental pharmacokinetics of a synthetic retinoid which is not bound by mouse embryonic cellular retinoic acid-binding protein.一种不与小鼠胚胎细胞视黄酸结合蛋白结合的合成类视黄醇的经胎盘药代动力学
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Single versus multiple dose administration of all-trans-retinoic acid during organogenesis: differential metabolism and transplacental kinetics in rat and rabbit.全反式维甲酸在器官形成期的单剂量与多剂量给药：大鼠和兔体内的代谢差异及经胎盘动力学
Toxicol Appl Pharmacol. 1995 Jan;130(1):9-18. doi: 10.1006/taap.1995.1002.
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Retinoids as teratogens.维甲酸作为致畸剂。
Annu Rev Nutr. 1995;15:111-32. doi: 10.1146/annurev.nu.15.070195.000551.
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Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure.维甲酸受体的选择性激动剂：比较毒代动力学和胚胎暴露情况。
Arch Toxicol. 2000 Jan;73(10-11):547-56. doi: 10.1007/s002040050007.

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Pretreatment Effect of Folic Acid on 13-Cis-RA-Induced Cellular Damage of Developing Midfacial Processes in Cultured Rat Embryos.叶酸对13-顺式维甲酸诱导的培养大鼠胚胎发育中面部过程细胞损伤的预处理作用
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Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling.用于非治疗应用的人类多能干细胞的神经分化：毒理学、药理学及体外疾病建模
Stem Cells Int. 2015;2015:105172. doi: 10.1155/2015/105172. Epub 2015 May 25.
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Present state and future perspectives of using pluripotent stem cells in toxicology research.
多能干细胞在毒理学研究中的应用现状及展望。
Arch Toxicol. 2011 Feb;85(2):79-117. doi: 10.1007/s00204-010-0641-6. Epub 2011 Jan 12.
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Teratogenicity of retinoic acid and its effects on TGF-beta2 expression in the developing cerebral cortex of the rat.维甲酸的致畸性及其对大鼠发育中大脑皮质转化生长因子-β2表达的影响。
J Mol Histol. 2004 Nov;35(8-9):823-7. doi: 10.1007/s10735-004-1683-y.
5
Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations.用于人类健康风险评估的发育神经毒性识别与特征描述方法。III：药代动力学和药效学考量
Environ Health Perspect. 2001 Mar;109 Suppl 1(Suppl 1):101-11. doi: 10.1289/ehp.01109s1101.
6
All-trans-retinol is a ligand for the retinoic acid receptors.全反式视黄醇是维甲酸受体的一种配体。
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7293-7. doi: 10.1073/pnas.90.15.7293.
7
The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid.兔子对13-顺式维甲酸（异维甲酸）致畸作用的高敏感性是胚胎长期暴露于13-顺式维甲酸和13-顺式-4-氧代维甲酸的结果，而非异构化为全反式维甲酸的结果。
Arch Toxicol. 1994;68(2):119-28. doi: 10.1007/s002040050044.
8
4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse.4-甲基吡唑部分改善了视黄醇的致畸性，并减少了小鼠体内全反式维甲酸的代谢生成。
Arch Toxicol. 1992;66(9):652-9. doi: 10.1007/BF01981505.