细菌群落中耐药性的进化与恶性组织之间的类比。
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.
机构信息
Department of Physics, Princeton University, Princeton, NJ 08544, USA.
出版信息
Nat Rev Cancer. 2011 May;11(5):375-82. doi: 10.1038/nrc3039.
Abstract
Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance in bacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and the evolution of cells within tumours.
摘要
癌细胞通过体细胞进化迅速产生药物耐药性，为了在转移阶段继续生长，它们违反了机体对调节生长和有益的共生相互作用的共识。我们认为，恶性组织内细胞群落对抗癌药物的耐药性迅速进化，以及细菌群落对抗生素的耐药性迅速进化之间存在着一种基本的机制联系。我们提出，这种进化是相互作用的细胞进行的程序化和集体应激反应的结果，并且鉴于这种基本联系，研究细菌群落可以更深入地了解肿瘤内细胞的适应动态和进化。
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