Fiani Nadine, Verstraete Frank J M, Kass Philip H, Cox Darren P
William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.
J Am Vet Med Assoc. 2011 Feb 15;238(4):495-500. doi: 10.2460/javma.238.4.495.
To characterize clinicopathologic features of the most common odontogenic tumors and focal fibrous hyperplasia (FFH) in dogs.
Retrospective case series.
152 dogs evaluated for oral tumors of possible odontogenic origin at the William R. Pritchard Veterinary Medical Teaching Hospital of the University of California-Davis between 1995 and 2005.
Information was collected from records, including dog breed, age, reproductive status, and location of lesion in the oral cavity. Histologic slides pertaining to each dog were reviewed by 3 investigators. Data regarding clinicopathologic features of the 3 most common lesions (canine acanthomatous ameloblastoma [CAA], peripheral odontogenic fibroma [POF], and FFH) were summarized.
152 dogs with odontogenic tumors or FFH were identified. Sixty-eight (45%) dogs had CAA, 47 (31 %) had POF, 24 (16%) had FFH, and 13 (9%) had other odontogenic tumors. Canine acanthomatous ameloblastoma was present most commonly in the rostral aspect of the mandible, with POF and FFH more common in the rostral aspect of the maxilla. Males and females were equally represented among dogs with CAA and FFH. Castrated males were overrepresented among dogs with POF. Golden Retrievers, Akitas, Cocker Spaniels, and Shetland Sheepdogs were overrepresented among dogs with CAA. No breed predisposition was detected for FFH or POF. Dogs with FFH had a greater mean age at initial evaluation than did dogs with CAA or POF.
CAA, POF, and FFH have distinct clinical patterns that may help clinicians and pathologists identify such lesions more readily.
描述犬类最常见的牙源性肿瘤和局灶性纤维增生（FFH）的临床病理特征。
回顾性病例系列研究。
1995年至2005年间，在加利福尼亚大学戴维斯分校威廉·R·普里查德兽医医学教学医院对152只可能起源于牙源性的口腔肿瘤犬进行评估。
从记录中收集信息，包括犬种、年龄、生殖状态以及口腔病变部位。由3名研究人员审查每只犬的组织学切片。总结了3种最常见病变（犬棘皮瘤型成釉细胞瘤 [CAA]、外周性牙源性纤维瘤 [POF] 和FFH）的临床病理特征数据。
共识别出152只患有牙源性肿瘤或FFH的犬。68只（45%）犬患有CAA, 47只（31%）患有POF, 24只（16%）患有FFH，13只（9%）患有其他牙源性肿瘤。犬棘皮瘤型成釉细胞瘤最常见于下颌骨的前端，而POF和FFH在上颌骨的前端更为常见。在患有CAA和FFH的犬中，雄性和雌性比例相当。在患有POF的犬中，去势雄性犬的比例过高。金毛寻回犬、秋田犬、可卡犬和设得兰牧羊犬在患有CAA的犬中占比过高。未检测到FFH或POF有品种易感性。与患有CAA或POF的犬相比，患有FFH的犬在初次评估时的平均年龄更大。
CAA、POF和FFH具有不同的临床模式，这可能有助于临床医生和病理学家更轻松地识别此类病变。
