Department of Pediatrics, Regina Margherita Children's Hospital, Piazza Polonia 94-10126, Turin, Italy.
World J Gastroenterol. 2011 Apr 21;17(15):1971-5. doi: 10.3748/wjg.v17.i15.1971.
To test if total ghrelin is present in infant formulas.
Using a radioimmunoassay, we measured total ghrelin concentrations in 19 samples of commercial infant formulas and in 20 samples of human milk. We also determined ghrelin concentration in the serum of infants and lactating mothers.
Ghrelin concentrations were significantly higher in artificial milk (2007.1 ± 1725.36 pg/mL) than in human milk (828.17 ± 323.32 pg/mL) (P = 0.005). The mean ghrelin concentration in infant serum (n = 56) was 1115.86 ± 42.89 pg/mL, and was significantly higher (P = 0.023) in formula-fed infants (1247.93 ± 328.07 pg/mL) than in breast-fed infants (1045.7 ± 263.38 pg/mL). The mean serum ghrelin concentration (mean ± SD) in lactating mothers (n = 20) was 1319.18 ± 140.18 pg/mL.
This study provides evidence that total ghrelin is present in infant formulas. This finding raises diverse questions regarding the uptake, absorption and metabolic effects of this hormone.
检测婴儿配方奶粉中是否存在总 ghrelin。
采用放射免疫分析法，检测 19 份商业婴儿配方奶粉和 20 份人乳样本中的总 ghrelin 浓度，并测定婴儿和哺乳期妇女血清中的 ghrelin 浓度。
人工奶（2007.1 ± 1725.36 pg/mL）中的 ghrelin 浓度明显高于人乳（828.17 ± 323.32 pg/mL）（P = 0.005）。56 例婴儿血清中 ghrelin 的平均浓度（n = 56）为 1115.86 ± 42.89 pg/mL，与母乳喂养的婴儿（1045.7 ± 263.38 pg/mL）相比，配方奶喂养的婴儿（1247.93 ± 328.07 pg/mL）的 ghrelin 浓度明显更高（P = 0.023）。20 名哺乳期妇女（n = 20）的血清 ghrelin 平均浓度（mean ± SD）为 1319.18 ± 140.18 pg/mL。
本研究提供了婴儿配方奶粉中存在总 ghrelin 的证据。这一发现提出了关于这种激素摄取、吸收和代谢作用的各种问题。
