Yoneda K
Department of Pathology, Veterans Administration Medical Center, Lexington, Kentucky 40511.
Cancer. 1990 Jan 1;65(1):164-8. doi: 10.1002/1097-0142(19900101)65:1<164::aid-cncr2820650131>3.0.co;2-r.
Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma constitutes a discrete group in reference to gross features, histologic and ultrastructural cell types, and the nature of the scar. The scar in Type I carcinomas appears mostly desmoplastic. The majority of Type II carcinomas appear to have arisen around a preexisting histoplasmosis granuloma which contains yeast organisms on microscopic examination. Pulmonary scar carcinoma is not a single discrete clinicopathologic entity. It appears that peripheral carcinomas of different histogenesis are incorporated in this category.
1985年至1988年期间，在某组织胞浆菌病流行地区的一家医院，对112例手术切除的肺癌进行检查，发现17例肺瘢痕癌。这些癌可分为两型：I型为黏液型；II型为非黏液型（克拉拉细胞型）。就大体特征、组织学和超微结构细胞类型以及瘢痕的性质而言，每一型癌均构成一个独立的组群。I型癌中的瘢痕大多呈促结缔组织增生性。II型癌中的大多数似乎是在先前存在的组织胞浆菌病肉芽肿周围发生的，显微镜检查可见该肉芽肿内含有酵母样菌体。肺瘢痕癌并非单一的、独立的临床病理实体。看来不同组织发生的周围型癌均归入此类。
