Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Singapore 117543.
ACS Nano. 2011 Jun 28;5(6):4670-8. doi: 10.1021/nn200500h. Epub 2011 May 11.
Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells' proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene's potential for stem cell research.
目前的组织工程方法将不同的支架材料与活细胞结合在一起，提供可以修复并最终改善组织功能的生物替代品。已经制造了天然和合成材料，用于干细胞的移植及其特定分化为肌肉、骨骼和软骨。骨再生治疗成功的一个关键目标是通过使用生长因子和成骨诱导剂来指导干细胞的增殖并以可控的方式加速其分化。在这里，我们表明石墨烯提供了一种有前途的生物相容性支架，不会阻碍人骨髓间充质干细胞（hMSC）的增殖，并加速其向成骨细胞的特异性分化。分化速度与常用生长因子相当，证明了石墨烯在干细胞研究中的潜力。
