Huang Jingtao, Li Aikang, Liang Rongji, Wu Xiaohao, Jia Shicheng, Chen Jiayou, Jiao Zilu, Li Canfeng, Zhang Xintao, Lin Jianjing
Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, Gunagdong Province, China.
Department of Clinical Medicine, Shantou University Medical College, Shantou, Gunagdong Province, China.
Biomater Transl. 2024 Nov 15;5(4):425-443. doi: 10.12336/biomatertransl.2024.04.007. eCollection 2024.
Bone and cartilage tissues are essential for movement and structure, yet diseases like osteoarthritis affect millions. Traditional therapies have limitations, necessitating innovative approaches. Organoid technology, leveraging stem cells' regenerative potential, offers a novel platform for disease modelling and therapy. This review focuses on advancements in bone/cartilage organoid technology, highlighting the role of stem cells, biomaterials, and external factors in organoid development. We discuss the implications of these organoids for regenerative medicine, disease research, and personalised treatment strategies, presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration. Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future, and promote the progress of biological tissue engineering.
骨骼和软骨组织对于运动和身体结构至关重要，但骨关节炎等疾病却影响着数百万人。传统疗法存在局限性，因此需要创新方法。类器官技术利用干细胞的再生潜力，为疾病建模和治疗提供了一个新平台。本综述聚焦于骨/软骨类器官技术的进展，突出干细胞、生物材料和外部因素在类器官发育中的作用。我们讨论了这些类器官对再生医学、疾病研究和个性化治疗策略的影响，将类器官视为增强软骨修复和骨再生的一条有前景的途径。骨/软骨类器官未来将在骨/软骨疾病的治疗中发挥更大作用，并推动生物组织工程的进步。
