Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Nutrition. 2011 Nov-Dec;27(11-12):1156-60. doi: 10.1016/j.nut.2010.12.019. Epub 2011 May 6.
Malnutrition frequently occurs in lung cancer patients. We aimed to determine nutritional status and antioxidant and mineral levels in Thai patients with lung cancer.
A prospective study with matched case-control was conducted. Nutritional status was assessed by body mass index (BMI) and subjective global assessment (SGA). Eastern Cooperative Oncology Group (ECOG) performance status was used to assess the performance. The serum antioxidant and mineral levels were determined.
Forty-nine patients with a mean age of 58.8 (range, 35-82) who were first diagnosed with lung cancer were enrolled. They were compared with 60 healthy controls, and levels of retinol, α-tocopherol, β-carotene, lycopene, β-cryptoxanthin, selenium, and zinc were lower (P < 0.05). However, peroxidase activity was higher (P = 0.002) in patients. Selenium levels were higher in early stage compared to advanced stage patients (P = 0.041). Overweight patients had higher selenium levels (0.04 mg/L) than normal BMI patients (β = 0.04, P = 0.035). Patients with SGA class C had lower selenium levels (0.03 mg/L) than those with class A (β = -0.03, P = 0.035). The poorer ECOG performance patients had significantly lower β-carotene (β = -0.192, P = 0.003) and selenium (β = -0.031, P = 0.011) levels compared with those with good ECOG performance status.
Significantly lower levels of antioxidants and selenium were found in lung cancer patients compared to healthy controls. Levels of some antioxidants and minerals differed among categories of BMI, SGA categories, or ECOG performance status. These findings may be helpful for further studies, such as the effect of nutritional supplementation on clinical outcomes.
营养不良在肺癌患者中很常见。我们旨在确定泰国肺癌患者的营养状况以及抗氧化剂和矿物质水平。
进行了一项前瞻性病例对照研究。通过体重指数（BMI）和主观整体评估（SGA）评估营养状况。采用东部合作肿瘤学组（ECOG）表现状态评估表现。测定血清抗氧化剂和矿物质水平。
共纳入 49 例平均年龄为 58.8 岁（范围 35-82 岁）的首次确诊为肺癌的患者，并与 60 例健康对照进行比较，结果显示患者的视黄醇、α-生育酚、β-胡萝卜素、番茄红素、β-隐黄质、硒和锌水平较低（P<0.05）。然而，患者的过氧化物酶活性较高（P=0.002）。与晚期患者相比，早期患者的硒水平较高（P=0.041）。超重患者的硒水平（0.04mg/L）高于正常 BMI 患者（β=0.04，P=0.035）。SGA 分级 C 的患者的硒水平（0.03mg/L）低于 SGA 分级 A 的患者（β=-0.03，P=0.035）。ECOG 表现较差的患者的β-胡萝卜素（β=-0.192，P=0.003）和硒（β=-0.031，P=0.011）水平明显低于 ECOG 表现良好的患者。
与健康对照组相比，肺癌患者的抗氧化剂和硒水平明显较低。BMI、SGA 分级或 ECOG 表现状态类别中，一些抗氧化剂和矿物质的水平存在差异。这些发现可能有助于进一步研究，如营养补充对临床结局的影响。
