Department of Veterinary Clinical Sciences, Royal Veterinary College, Hertfordshire, UK.
Epilepsy Behav. 2011 Jun;21(2):160-7. doi: 10.1016/j.yebeh.2011.03.018. Epub 2011 May 4.
The aim of the study was to demonstrate behavioral changes with the development of epilepsy in dogs, a species proposed as a naturally occurring animal model for human epilepsy.
Owners of dogs diagnosed with idiopathic epilepsy (n=80) completed a modified, previously-validated behavioral and seizure questionnaire. Principal axis factor analysis identified behavioral factors, the scores for which were compared before and after the development of epilepsy.
Drug-naïve dogs showed an increase in the behavior factors Fear/Anxiety, Defensive Aggression, and Abnormal Perception. In dogs receiving antiepileptic medication, there were still increases in Fear/Anxiety and Abnormal Perception, but no longer in Defensive Aggression. Additional increases were observed in Abnormal Reactivity, Attachment Disorder, Demented Behavior, and Apathetic Behavior. Pharmacoresistant dogs had larger increases in Controlling Aggression, Abnormal Perception, and Demented Behavior than drug responders.
Our data suggest that dogs, like humans and rodents, exhibit neurobehavioral comorbidities with the development of epilepsy.
本研究旨在展示犬类癫痫发病过程中的行为变化,犬类被认为是一种自然发生的人类癫痫动物模型。
被诊断为特发性癫痫的犬类主人(n=80)填写了一份改良的、先前经过验证的行为和癫痫发作问卷。主成分因子分析确定了行为因素,并比较了癫痫发病前后的得分。
在未接受药物治疗的犬中,恐惧/焦虑、防御性攻击和异常知觉等行为因素增加。在接受抗癫痫药物治疗的犬中,恐惧/焦虑和异常知觉仍然增加,但防御性攻击不再增加。此外,还观察到异常反应性、依恋障碍、痴呆行为和冷漠行为的增加。与药物反应者相比,耐药犬的控制攻击性、异常知觉和痴呆行为增加幅度更大。
我们的数据表明,犬类与人类和啮齿动物一样,在癫痫发病过程中会出现神经行为合并症。